p38a p38a MAP kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: p38aprovided by FlyBase
Official Full Name: p38a MAP kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0015765
Locus tag: Dmel_CG5475
See related: AllianceGenome:FB:FBgn0015765
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5475; D-MPK2; D-p38; D-p38 MAPK; D-p38a; D-P38a; dERK2; Dmel\CG5475; DmMPK2; Dmp38a; dMPK2; DMPK2; dp38; Dp38; dp38a; Dp38a; Erk2; ERK2; group 2; MAPK-2; MAPK2; mpk2; Mpk2; MPK2; p38; P38; p38 alpha; p38 MAPK; p38A; p38alpha; p38K; p38Ka; p38MAPK; p38[MAPK]
Summary: Enables MAP kinase activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and p38MAPK cascade. Located in nucleus. Is expressed in adult head; embryonic midgut chamber; embryonic primordium of adult hindgut precursor; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK11 (mitogen-activated protein kinase 11) and MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 95E5-95E5; 3-83 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24150416..24152321, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19976138..19978043, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERK2 Mutations Affect Interactions, Localization, and Dimerization.
Title: ERK2 Mutations Affect Interactions, Localization, and Dimerization.
Two upstream kinases, apoptotic signal-regulating kinase 1 (Ask1) and Licorne MAP kinase kinase 3 (MKK3), are required for p38 MAP kinase (p38) activation following infection, oxidative stress, detergent exposure and wounding.
Title: Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut.
The results revealed that the high-fat diet augmented the rate of lipid peroxidation and SOD and CAT activity and induced a higher expression of HSP83 and MPK2 mRNA.
Title: High-Fat Diet Induces Oxidative Stress and MPK2 and HSP83 Gene Expression in Drosophila melanogaster.
found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles
Title: High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy.
The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection.
Title: Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi.
the D-p38a gene is required to mediate some, but not all, of the functions ascribed to p38 signalling
Title: A Drosophila p38 orthologue is required for environmental stress responses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables MAP kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in MAPK cascade	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to arsenic-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in mucosal immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of antimicrobial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in paracrine signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of adult chitin-containing cuticle pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: p38a MAP kinase

Names: CG5475-PA; CG5475-PB; CG5475-PC; Erk-kinase-like; Mpk2; p38 MAP kinase; p38 mitogen-activated protein kinase; p38a-PA; p38a-PB; p38a-PC; stress-activated kinase P38

NP_001163711.1

EC 2.7.11.1

EC 2.7.11.24

NP_477163.1

EC 2.7.11.1

EC 2.7.11.24

NP_732959.1

EC 2.7.11.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24150416..24152321 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170126.5 → NP_732959.1 p38a MAP kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732959.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3C0, O46216, O62618, Q9TXB4

UniProtKB/TrEMBL

E1JIV6

Related

FBpp0083966

Conserved Domains (2) summary

cd07851
Location:9 → 354

STKc_p38; Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase

smart00220
Location:25 → 312

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_057815.5 → NP_477163.1 p38a MAP kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477163.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3C0, O46216, O62618, Q9TXB4

UniProtKB/TrEMBL

E1JIV6

Related

FBpp0083965

Conserved Domains (2) summary

cd07851
Location:9 → 354

STKc_p38; Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase

smart00220
Location:25 → 312

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_001170240.2 → NP_001163711.1 p38a MAP kinase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163711.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3C0, O46216, O62618, Q9TXB4

UniProtKB/TrEMBL

E1JIV6

Conserved Domains (2) summary

cd07851
Location:9 → 354

STKc_p38; Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase

smart00220
Location:25 → 312

S_TKc; Serine/Threonine protein kinases, catalytic domain