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CG13605 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42858, updated on 9-Dec-2024

Summary

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Official Symbol
CG13605provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039150
Locus tag
Dmel_CG13605
See related
AllianceGenome:FB:FBgn0039150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG13605
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in positive regulation of ERAD pathway. Is expressed in adult head and organism. Orthologous to several human genes including RNFT2 (ring finger protein, transmembrane 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG13605 in Genome Data Viewer
Location:
95E1-95E1; 3-83 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24109944..24112389, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19935666..19938111, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E homologous protein Neighboring gene Syntaxin 1A Neighboring gene transfer RNA:Leucine-TAA 2-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rootletin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article
  2. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article
  3. Nociceptor-Enriched Genes Required for Normal Thermal Nociception. Honjo K, et al. Cell Rep, 2016 Jul 12. PMID 27346357, Free PMC Article
  4. Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos. Sopko R, et al. Dev Cell, 2014 Oct 13. PMID 25284370, Free PMC Article
  5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG13605-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24109944..24112389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142957.3 → NP_651214.2  uncharacterized protein Dmel_CG13605 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651214.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U148, Q8MT73, Q9VCD3
    Conserved Domains (1) summary
    cd00162
    Location:610 → 651
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MT73 Q8MT73
Q9VCD3 Q9VCD3

Gene LinkOut

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