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Rox8 Rox8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42848, updated on 9-Dec-2024

Summary

Official Symbol
Rox8provided by FlyBase
Official Full Name
Rox8provided by FlyBase
Primary source
FLYBASE:FBgn0005649
Locus tag
Dmel_CG5422
See related
AllianceGenome:FB:FBgn0005649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5422; Dmel\CG5422; DmTIAR; dTIAR; Rbp12; Rox-8; rox8; ROX8; rrm12; RRM12; TIAR
Summary
Enables mRNA 3'-UTR binding activity and protein-RNA adaptor activity. Involved in several processes, including negative regulation of organ growth; positive regulation of hippo signaling; and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of U1 snRNP. Is expressed in several structures, including adult head; central brain primordium; cuboidal/columnar epithelium; germline cell; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to several human genes including TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Rox8 in Genome Data Viewer
Location:
95D9-95D10; 3-82 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24043056..24048265, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19868778..19873987, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Methyltransferase like 3 Neighboring gene Mitochondrial Rho Neighboring gene spastin Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 6 Neighboring gene Phosphatidylserine decarboxylase

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein-RNA adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of U1 snRNP ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
Rox8
Names
CG5422-PB
CG5422-PC
CG5422-PD
CG5422-PE
CG5422-PG
CG5422-PH
RNA-binding protein 12
Rox8-PB
Rox8-PC
Rox8-PD
Rox8-PE
Rox8-PG
Rox8-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24043056..24048265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170119.2NP_732945.1  Rox8, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732945.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMX4, Q8SZP5
    Related
    FBpp0083976
    Conserved Domains (4) summary
    cd12352
    Location:980
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5274
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  2. NM_170116.2NP_732942.1  Rox8, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732942.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q08212, Q9VCE3
    Related
    FBpp0083977
    Conserved Domains (4) summary
    cd12352
    Location:980
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5274
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  3. NM_170117.2NP_732943.1  Rox8, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732943.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q08212, Q9VCE3
    Related
    FBpp0083979
    Conserved Domains (4) summary
    cd12352
    Location:980
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5274
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  4. NM_001275969.1NP_001262898.1  Rox8, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262898.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMX4, Q8SZP5
    Conserved Domains (4) summary
    cd12352
    Location:980
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5274
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  5. NM_001275968.1NP_001262897.1  Rox8, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262897.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMX4, Q8SZP5
    Conserved Domains (4) summary
    cd12352
    Location:980
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5274
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  6. NM_170118.2NP_732944.2  Rox8, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732944.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMX4, Q8SZP5
    Conserved Domains (4) summary
    cd12352
    Location:980
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5274
    ELAV_HUD_SF; ELAV/HuD family splicing factor