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Rox8 Rox8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42848, updated on 4-Jan-2025

Summary

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Official Symbol
Rox8provided by FlyBase
Official Full Name
Rox8provided by FlyBase
Primary source
FLYBASE:FBgn0005649
Locus tag
Dmel_CG5422
See related
AllianceGenome:FB:FBgn0005649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5422; Dmel\CG5422; DmTIAR; dTIAR; Rbp12; Rox-8; rox8; ROX8; rrm12; RRM12; TIAR
Summary
Enables mRNA 3'-UTR binding activity and protein-RNA adaptor activity. Involved in several processes, including negative regulation of organ growth; positive regulation of hippo signaling; and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of U1 snRNP. Is expressed in several structures, including adult head; central brain primordium; cuboidal/columnar epithelium; germline cell; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to several human genes including TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Rox8 in Genome Data Viewer
Location:
95D9-95D10; 3-82 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24043056..24048265, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19868778..19873987, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Methyltransferase like 3 Neighboring gene Mitochondrial Rho Neighboring gene spastin Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 6 Neighboring gene Phosphatidylserine decarboxylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of synaptic Pumilio function by an aggregation-prone domain. Salazar AM, et al. J Neurosci, 2010 Jan 13. PMID 20071514, Free PMC Article
  2. The developmentally-regulated Drosophila gene rox8 encodes an RRM-type RNA binding protein structurally related to human TIA-1-type nucleolysins. Brand S, et al. Nucleic Acids Res, 1993 Aug 11. PMID 8396236, Free PMC Article
  3. Novel Drosophila melanogaster genes encoding RRM-type RNA-binding proteins identified by a degenerate PCR strategy. Brand SF, et al. Gene, 1995 Mar 10. PMID 7890163
  4. Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. Sherwood NT, et al. PLoS Biol, 2004 Dec. PMID 15562320, Free PMC Article
  5. Enhancing Mitofusin/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies. Khalil B, et al. Neurobiol Aging, 2017 Jun. PMID 28324764

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein-RNA adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of miRNA-mediated gene silencing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U1 snRNP ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
Rox8
Names
CG5422-PB
CG5422-PC
CG5422-PD
CG5422-PE
CG5422-PG
CG5422-PH
RNA-binding protein 12
Rox8-PB
Rox8-PC
Rox8-PD
Rox8-PE
Rox8-PG
Rox8-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24043056..24048265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170119.2 → NP_732945.1  Rox8, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732945.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMX4, Q8SZP5
    Related
    FBpp0083976
    Conserved Domains (4) summary
    cd12352
    Location:9 → 80
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96 → 170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221 → 294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5 → 274
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  2. NM_170116.2 → NP_732942.1  Rox8, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732942.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q08212, Q9VCE3
    Related
    FBpp0083977
    Conserved Domains (4) summary
    cd12352
    Location:9 → 80
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96 → 170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221 → 294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5 → 274
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. NM_170117.2 → NP_732943.1  Rox8, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732943.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q08212, Q9VCE3
    Related
    FBpp0083979
    Conserved Domains (4) summary
    cd12352
    Location:9 → 80
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96 → 170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221 → 294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5 → 274
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  4. NM_001275969.1 → NP_001262898.1  Rox8, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262898.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMX4, Q8SZP5
    Conserved Domains (4) summary
    cd12352
    Location:9 → 80
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96 → 170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221 → 294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5 → 274
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  5. NM_001275968.1 → NP_001262897.1  Rox8, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262897.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMX4, Q8SZP5
    Conserved Domains (4) summary
    cd12352
    Location:9 → 80
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96 → 170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221 → 294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5 → 274
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  6. NM_170118.2 → NP_732944.2  Rox8, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732944.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMX4, Q8SZP5
    Conserved Domains (4) summary
    cd12352
    Location:9 → 80
    RRM1_TIA1_like; RNA recognition motif 1 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12353
    Location:96 → 170
    RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
    cd12354
    Location:221 → 294
    RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    TIGR01661
    Location:5 → 274
    ELAV_HUD_SF; ELAV/HuD family splicing factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08212 Q08212
Q26281 Q26281
Q8IMX4 Q8IMX4
Q8SZP5 Q8SZP5
Q9VCE3 Q9VCE3

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