Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search NCBI

spas - spastin

Enables microtubule binding activity and microtubule severing ATPase activity. Involved in several processes, including regulation of microtubule depolymerization; regulation of nervous system development; and regulation of neuromuscular synaptic transmission. Located in several cellular components, including centrosome; neuromuscular junction; and terminal bouton. Colocalizes with synaptic vesicle. Is expressed in several structures, including anterior midgut primordium; cephalic furrow; embryonic neuromere; embryonic/larval head sense organ; and ganglia. Used to study hereditary spastic paraplegia and hereditary spastic paraplegia 4. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to spas

NCBI Orthologs

How was this calculated?

genes for:

Protein alignment

Align

Download data

Download
Species Gene Architecture aa