Hmgcr HMG Coenzyme A reductase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hmgcrprovided by FlyBase
Official Full Name: HMG Coenzyme A reductaseprovided by FlyBase
Primary source: FLYBASE:FBgn0263782
Locus tag: Dmel_CG10367
See related: AllianceGenome:FB:FBgn0263782
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD15354; bro1; bs32f05.y1; CG10367; clb; Clb; Dmel\CG10367; DmHMG-CoAr; Hmg; HmG-CoAR; hmgc; HMGCoAr; HMGCoAR; HMGCoARr; hmgcr; HMGCR; HMGCR_Dm; HMGR; hmgrc; l(3)01152; l(3)04684
Summary: Predicted to enable hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in several processes, including ecdysis, chitin-based cuticle; embryonic heart tube development; and germ cell attraction. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in several structures, including adult brain cell body rind; adult fat body; anterior-posterior subdivision of organism; gut section; and visceral mesoderm derivative. Used to study myopathy. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 95B1-95B1; 3-80 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23733324..23750992)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19559046..19576714)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrate that the attractive signal downstream of Hmgcr is cell-contact independent and acts at long range, the extent of which depends on Hmgcr levels. This range would be sufficient to reach all of the germ cells for their entire migration. Furthermore, Hmgcr-mediated attraction does not require Wunens but can operate simultaneously with Wunen-mediated repulsion.
Title: Hmgcr promotes a long-range signal to attract Drosophila germ cells independently of Hedgehog.
The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos.
Title: Isoprenoids control germ cell migration downstream of HMGCoA reductase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in coenzyme A metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ecdysis, chitin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell attraction	IDA Inferred from Direct Assay more info	PubMed
involved_in germ cell attraction	TAS Traceable Author Statement more info	PubMed
involved_in germ cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	TAS Traceable Author Statement more info	PubMed
involved_in gonad development	TAS Traceable Author Statement more info	PubMed
involved_in isoprenoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Ras protein signal transduction	HGI more info	PubMed
involved_in sterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: HMG coenzyme A reductase

Names: 3-Hydroxy-3-Methylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl coenzyme A reductase; CG10367-PA; HMG-CoA reductase; HMG-CoA reductase class I; HMGCo-A reductase; HMGCoA reductase; Hmg-CoA-reductase; Hmgcr-PA; columbus; lethal (3) 04684

NP_732900.1

EC 1.1.1.-

EC 1.1.1.34

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23733324..23750992

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170089.2 → NP_732900.1 HMG coenzyme A reductase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732900.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3A8, P14773, Q9VCI8

UniProtKB/TrEMBL

A9UN11, E1JIU8

Related

FBpp0083842

Conserved Domains (3) summary

cd00643
Location:489 → 897

HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)

TIGR00920
Location:1 → 920

2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

cl21543
Location:133 → 263

MMPL; MMPL family