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CG4408 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42762, updated on 9-Dec-2024

Summary

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Official Symbol
CG4408provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039073
Locus tag
Dmel_CG4408
See related
AllianceGenome:FB:FBgn0039073
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GH09055; Dmel\CG4408
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in adult head and organism. Orthologous to human CPA5 (carboxypeptidase A5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG4408 in Genome Data Viewer
Location:
94E13-94E13; 3-78 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23361889..23363574, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19187611..19189296, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Secretory 13 Neighboring gene Ribosomal protein S3 Neighboring gene long non-coding RNA:CR44322 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNApol-ϵ gene is indispensable for the survival and growth of Drosophila melanogaster. Verma A, et al. Genesis, 2012 Feb. PMID 21898761
  2. The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. Lim DH, et al. FEBS Lett, 2011 Oct 3. PMID 21889502
  3. Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase. Radyuk SN, et al. Mech Ageing Dev, 2012 Jun. PMID 22579812
  4. Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. Nagoshi E, et al. Nat Neurosci, 2010 Jan. PMID 19966839, Free PMC Article
  5. Burst of young retrogenes and independent retrogene formation in mammals. Pan D, et al. PLoS One, 2009. PMID 19325906, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4408-PA
CG4408-PB
Dmel_CG4408
NP_001287482.1
NP_651141.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23361889..23363574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142884.2 → NP_651141.2  uncharacterized protein Dmel_CG4408, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651141.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3M3A3, Q9VCM8
    Related
    FBpp0083823
    Conserved Domains (2) summary
    cd03860
    Location:179 → 472
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam02244
    Location:88 → 159
    Propep_M14; Carboxypeptidase activation peptide

  2. NM_001300553.1 → NP_001287482.1  uncharacterized protein Dmel_CG4408, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287482.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3M3A3, Q7JVX3
    Conserved Domains (2) summary
    cd03860
    Location:167 → 460
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam02244
    Location:76 → 147
    Propep_M14; Carboxypeptidase activation peptide
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JVX3 Q7JVX3
Q9VCM8 Q9VCM8

Gene LinkOut

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