pnt pointed [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pntprovided by FlyBase
Official Full Name: pointedprovided by FlyBase
Primary source: FLYBASE:FBgn0003118
Locus tag: Dmel_CG17077
See related: AllianceGenome:FB:FBgn0003118
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0123/09; 0608/07; 0998/12; 3520; CG17077; D-ets-2; D-Ets-2; Dmel\CG17077; DMPOINT1A; E(E2F)3D; EC3-2; EK3-2; Ets; Ets1/2; Ets2; ETS2; Ets58AB; ets94F; Ets94F; EY3-1; l(3)07825; l(3)j1B7; l(3)s118306; png; Pnt; PNT; pnt-P1; Pnt-P1; PNT-P1; pnt-P2; pnt.P1; Pnt2; pntegfr; PntP1; PNTP1; pntP2; PntP2; PNTP2; POINT; Pointed; Pointed-P1; pointed-RC; ptd
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; larval lymph gland hemocyte differentiation; and morphogenesis of an epithelium. Located in nucleus. Is expressed in several structures, including glial cell; gut section; imaginal disc; organism subdivision; and somatic precursor cell. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ETS1 (ETS proto-oncogene 1, transcription factor) and ETS2 (ETS proto-oncogene 2, transcription factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 94E9-94E13; 3-78 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23290231..23346167, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19115953..19171889, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrative genomic analyses reveal putative cell type-specific targets of the Drosophila ets transcription factor Pointed.
Title: Integrative genomic analyses reveal putative cell type-specific targets of the Drosophila ets transcription factor Pointed.
The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.
Title: The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.
DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm.
Title: DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm.
The ETS-transcription factor Pointed is sufficient to regulate the posterior fate of the follicular epithelium.
Title: The ETS-transcription factor Pointed is sufficient to regulate the posterior fate of the follicular epithelium.
A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition.
Title: A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition.
Pnt is important for adults facing nutritional variation or stress.
Title: Longevity is determined by ETS transcription factors in multiple tissues and diverse species.
a new layer of regulation whereby Yan and Pointed co-occupy regulatory elements to repress gene expression in a coordinated manner, with Pointed being unexpectedly required for the genome-wide occupancy of both Yan and the co-repressor Groucho.
Title: Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila.
results demonstrate that PntP1 prevents both the premature differentiation and the dedifferentiation of INPs by regulating the expression of distinct target genes at different stages of imINP development.
Title: The Ets protein Pointed prevents both premature differentiation and dedifferentiation of Drosophila intermediate neural progenitors.
Both PntP1 and PntP2 are required for oenocyte specification. Since PntP1 is a downstream effector of EGF signaling, these findings provide insight into how a Hox factor can both trigger and potentiate the EGF signal to promote an essential cell fate along the body plan.
Title: A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes.
PntP2 transcription factor plays a role in air sac development by regulation of the EGF ligand Vein protein.
Title: FGF coordinates air sac development by activation of the EGF ligand Vein through the transcription factor PntP2.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0103 (e-PCR)
- UniSTS:78457

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in R3/R4 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R7 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell dedifferentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell dedifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of genital disc primordium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc proximal/distal pattern formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in lymph gland crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland plasmatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cardioblast cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oenocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in secondary branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sevenless signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in sevenless signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal cell fate specification, open tracheal system	HMP more info	PubMed
involved_in trachea development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: pointed

Names: CG17077-PB; CG17077-PC; CG17077-PD; CG17077-PE; Ets at 58AB; Ets protein pointed P2; Point2; Pointed2; no terminal cell clones-R; pnt-PB; pnt-PC; pnt-PD; pnt-PE; pointed P1; pointed P2; pointed-P1; pointed-P2; pointedP2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23290231..23346167 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079737.3 → NP_524461.2 pointed, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524461.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4KH96, B9EQV8, H8F4R1, P19420, P51022, P51023, Q29R53, Q8IG92, Q8IMZ1, Q9VCN2

Related

FBpp0088658

Conserved Domains (2) summary

cd08533
Location:179 → 250

SAM_PNT-ETS-1,2; Sterile alpha motif (SAM)/Pointed domain of ETS-1,2 family

smart00413
Location:609 → 693

ETS; erythroblast transformation specific domain
NM_001275943.1 → NP_001262872.1 pointed, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262872.1

Status: REVIEWED

UniProtKB/TrEMBL

N0D853

Conserved Domains (1) summary

smart00413
Location:516 → 600

ETS; erythroblast transformation specific domain
NM_170651.4 → NP_732857.1 pointed, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732857.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P51023

UniProtKB/TrEMBL

H8F4R1

Related

FBpp0088657

Conserved Domains (2) summary

cd08533
Location:97 → 168

SAM_PNT-ETS-1,2; Sterile alpha motif (SAM)/Pointed domain of ETS-1,2 family

smart00413
Location:527 → 611

ETS; erythroblast transformation specific domain
NM_170070.2 → NP_732858.1 pointed, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732858.1

Status: REVIEWED

UniProtKB/TrEMBL

N0D853

Related

FBpp0088656

Conserved Domains (1) summary

smart00413
Location:514 → 598

ETS; erythroblast transformation specific domain