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CG6763 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42754, updated on 4-Jan-2025

Summary

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Official Symbol
CG6763provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039069
Locus tag
Dmel_CG6763
See related
AllianceGenome:FB:FBgn0039069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6763
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic Malpighian tubule. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG6763 in Genome Data Viewer
Location:
94E9-94E9; 3-78 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23284002..23286041)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19109724..19111763)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Peroxin 11c Neighboring gene oo18 RNA-binding protein Neighboring gene Cell division cycle 16 Neighboring gene wampa Neighboring gene big bubble 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article
  2. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  3. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
  4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
  5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6763-PA
CG6763-PB
NP_001262871.1
NP_651138.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23284002..23286041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142881.3 → NP_651138.1  uncharacterized protein Dmel_CG6763, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651138.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCN5
    Related
    FBpp0083770
    Conserved Domains (2) summary
    cd04280
    Location:119 → 300
    ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
    pfam01400
    Location:116 → 304
    Astacin; Astacin (Peptidase family M12A)

  2. NM_001275942.1 → NP_001262871.1  uncharacterized protein Dmel_CG6763, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262871.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCN5
    Conserved Domains (2) summary
    cd04280
    Location:119 → 300
    ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
    pfam01400
    Location:116 → 304
    Astacin; Astacin (Peptidase family M12A)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCN5 Q9VCN5

Gene LinkOut

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