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fzo fuzzy onions [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42745, updated on 4-Jan-2025

Summary

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Official Symbol
fzoprovided by FlyBase
Official Full Name
fuzzy onionsprovided by FlyBase
Primary source
FLYBASE:FBgn0011596
Locus tag
Dmel_CG4568
See related
AllianceGenome:FB:FBgn0011596
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0125274.1; anon-WO0125274.25; anon-WO0125274.26; CG4568; Dmel\CG4568; Fzo; mfn1; MFN1
Summary
Predicted to enable GTPase activity. Involved in Nebenkern assembly; mitochondrion organization; and positive regulation of mitochondrial fusion. Located in mitochondrial envelope. Is expressed in several structures, including Nebenkern; embryonic hypopharynx; hypopharynx proper primordium; male germline cell; and testis. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See fzo in Genome Data Viewer
Location:
94E6-94E6; 3-78 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23201644..23204034, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19027366..19029756, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Inwardly rectifying potassium channel 1 Neighboring gene uncharacterized protein Neighboring gene cap-n-collar Neighboring gene uncharacterized protein Neighboring gene Rad60

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial morphogenesis: fusion factor for fly fertility. Yaffe MP. Curr Biol, 1997 Dec 1. PMID 9382824
  2. Mitochondrial dynamics during spermatogenesis. Varuzhanyan G, et al. J Cell Sci, 2020 Jul 16. PMID 32675215, Free PMC Article
  3. A fuzzy mitochondrial fusion apparatus comes into focus. Mozdy AD, et al. Nat Rev Mol Cell Biol, 2003 Jun. PMID 12778126
  4. Mitochondrial division: New partners in membrane pinching. Yoon Y, et al. Curr Biol, 2001 Jan 23. PMID 11231145
  5. Dynamic mitochondria. Yaffe MP. Nat Cell Biol, 1999 Oct. PMID 10559975

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in Nebenkern assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial fusion TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitochondrion localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrial envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fuzzy onions
Names
CG4568-PA
fzo-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23201644..23204034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170060.2 → NP_732840.1  fuzzy onions [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732840.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18412, Q4V3Y6, Q9VCP7
    Related
    FBpp0083791
    Conserved Domains (2) summary
    cd09912
    Location:87 → 334
    DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
    pfam04799
    Location:572 → 716
    Fzo_mitofusin; fzo-like conserved region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18412.2 O18412

Gene LinkOut

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