VhaAC39-2 Vacuolar H[+] ATPase AC39 subunit 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: VhaAC39-2provided by FlyBase
Official Full Name: Vacuolar H[+] ATPase AC39 subunit 2provided by FlyBase
Primary source: FLYBASE:FBgn0039058
Locus tag: Dmel_CG4624
See related: AllianceGenome:FB:FBgn0039058
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.227; CG4624; Dmel\CG4624; V0d; vhaAC39-2
Summary: Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Involved in terminal branching, open tracheal system. Predicted to be part of plasma membrane proton-transporting V-type ATPase complex and vacuolar proton-transporting V-type ATPase complex. Predicted to be active in early endosome. Is expressed in adult head. Orthologous to human ATP6V0D1 (ATPase H+ transporting V0 subunit d1) and ATP6V0D2 (ATPase H+ transporting V0 subunit d2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23158017..23159316, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18983739..18985038, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATPase activity, rotational mechanism	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IC Inferred by Curator more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
part_of plasma membrane proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting V-type ATPase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info

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