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CenB1A Centaurin beta 1A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42735, updated on 4-Jan-2025

Summary

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Official Symbol
CenB1Aprovided by FlyBase
Official Full Name
Centaurin beta 1Aprovided by FlyBase
Primary source
FLYBASE:FBgn0039056
Locus tag
Dmel_CG6742
See related
AllianceGenome:FB:FBgn0039056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACAP; Cen1ba; cenB1A; CG6742; Dmel\CG6742
Summary
Predicted to enable GTPase activator activity and phospholipid binding activity. Predicted to be located in membrane. Is expressed in several structures, including Malpighian tubule main body primordium; adult Dh44 neuron of pars intercerebralis; anlage in statu nascendi; gut section; and larval ring gland projection neurons. Orthologous to several human genes including ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1) and ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CenB1A in Genome Data Viewer
Location:
94E1-94E1; 3-78 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23118400..23124217)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18944122..18949939)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Carrier of Wingless Neighboring gene uncharacterized protein Neighboring gene Ras association family member Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hedgehog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The winged-helix transcription factor JUMU is a haplo-suppressor/triplo-enhancer of PEV in various tissues but exhibits reverse PEV effects in the brain of Drosophila melanogaster. Hofmann A, et al. Chromosome Res, 2009. PMID 19301136
  2. In vivo role of a potassium channel-binding protein in regulating neuronal excitability and behavior. Shahidullah M, et al. J Neurosci, 2009 Oct 21. PMID 19846720, Free PMC Article
  3. Ancient complexity, opisthokont plasticity, and discovery of the 11th subfamily of Arf GAP proteins. Schlacht A, et al. Traffic, 2013 Jun. PMID 23433073, Free PMC Article
  4. Innervation of the ring gland of Drosophila melanogaster. Siegmund T, et al. J Comp Neurol, 2001 Mar 19. PMID 11223816
  5. Rab11 regulates cell-cell communication during collective cell movements. Ramel D, et al. Nat Cell Biol, 2013 Mar. PMID 23376974, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
centaurin beta 1A
Names
CG6742-PA
CG6742-PB
CenB1A-PA
CenB1A-PB
centaurin beta1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23118400..23124217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079734.5 → NP_524458.1  centaurin beta 1A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524458.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0R1, Q9VCQ6
    Related
    FBpp0083761
    Conserved Domains (7) summary
    cd07603
    Location:18 → 217
    BAR_ACAPs; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing proteins
    cd00204
    Location:652 → 768
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:260 → 355
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:259 → 352
    PH; PH domain
    pfam01412
    Location:384 → 497
    ArfGap; Putative GTPase activating protein for Arf
    pfam13637
    Location:683 → 736
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:687 → 713
    ANK; ANK repeat [structural motif]

  2. NM_170049.4 → NP_732826.2  centaurin beta 1A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732826.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH23, Q7KS50
    Related
    FBpp0083762
    Conserved Domains (6) summary
    cd00204
    Location:422 → 538
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13250
    Location:23 → 125
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    pfam00169
    Location:22 → 122
    PH; PH domain
    pfam01412
    Location:154 → 267
    ArfGap; Putative GTPase activating protein for Arf
    pfam13637
    Location:453 → 506
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:457 → 483
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KS50 Q7KS50
Q8MSZ5 Q8MSZ5
Q8T0R1 Q8T0R1
Q9VCQ6 Q9VCQ6

Gene LinkOut

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