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Nha2 Na[+]/H[+] hydrogen antiporter 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42710, updated on 9-Dec-2024

Summary

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Official Symbol
Nha2provided by FlyBase
Official Full Name
Na[+]/H[+] hydrogen antiporter 2provided by FlyBase
Primary source
FLYBASE:FBgn0263390
Locus tag
Dmel_CG43442
See related
AllianceGenome:FB:FBgn0263390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31052; CG43205; CG43442; CG4682; CG4693; Dmel\CG43442; DMG8-chr3R.34.001; DmNHA2; nha2; tango12; Tango12; TANGO12
Old locus tag
Dmel_CG31052
Summary
Enables sodium:proton antiporter activity and solute:potassium antiporter activity. Involved in potassium ion transmembrane transport; protein secretion; and renal sodium ion transport. Located in Golgi apparatus and brush border. Is expressed in Malpighian tubule; adult head; embryonic large intestine; and hindgut. Orthologous to human SLC9B1 (solute carrier family 9 member B1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Nha2 in Genome Data Viewer
Location:
94D6-94D7; 3-77 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22981459..22998528, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18807181..18824250, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Transition protein-like 94D Neighboring gene Growth-blocking peptide 3 Neighboring gene Odorant receptor 94a Neighboring gene Odorant receptor 94b Neighboring gene antisense RNA:CR43454 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44225

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Chintapalli VR, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324901, Free PMC Article
  2. Evolutionary origins of eukaryotic sodium/proton exchangers. Brett CL, et al. Am J Physiol Cell Physiol, 2005 Feb. PMID 15643048
  3. Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. Day JP, et al. J Cell Sci, 2008 Aug 1. PMID 18628302
  4. The Drosophila Malpighian tubule as a model for mammalian tubule function. Rodan AR. Curr Opin Nephrol Hypertens, 2019 Sep. PMID 31268918, Free PMC Article
  5. Updates on ion and water transport by the Malpighian tubule. Dow JAT, et al. Curr Opin Insect Sci, 2021 Oct. PMID 33705976, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NHA1 and NHA2 are essential for survival, but have distinct transport modalities
    Title: Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities.
  2. CG31052 is a member of the CPA2 gene family, colocalise to the same apical membrane as the plasma membrane V-ATPase and show distinct ion specificities, as expected for the Wieczorek exchanger.
    Title: Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables solute:potassium antiporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in inorganic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in renal sodium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Na[+]/H[+] hydrogen antiporter 2
Names
CG43442-PA
CG43442-PB
Nha2-PA
Nha2-PB
transport and golgi organization 12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22981459..22998528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260322.1 → NP_001247251.1  Na[+]/H[+] hydrogen antiporter 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247251.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6G5
    Conserved Domains (1) summary
    cl01133
    Location:279 → 686
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  2. NM_170043.2 → NP_732807.1  Na[+]/H[+] hydrogen antiporter 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732807.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U48, Q9VCS7
    Related
    FBpp0301108
    Conserved Domains (1) summary
    cl01133
    Location:149 → 556
    Na_H_Exchanger; Sodium/hydrogen exchanger family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6G5 A0A0B4K6G5
Q9VCS7 Q9VCS7

Gene LinkOut

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