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klg klingon [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42707, updated on 9-Dec-2024

Summary

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Official Symbol
klgprovided by FlyBase
Official Full Name
klingonprovided by FlyBase
Primary source
FLYBASE:FBgn0017590
Locus tag
Dmel_CG6669
See related
AllianceGenome:FB:FBgn0017590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6669; CT20712; Dmel\CG6669; h214; Klg; l(3)rN712
Summary
Predicted to enable axon guidance receptor activity. Involved in several processes, including behavioral response to ethanol; homophilic cell adhesion via plasma membrane adhesion molecules; and long-term memory. Predicted to be extrinsic component of plasma membrane. Predicted to be active in axon; neuronal cell body; and plasma membrane. Is expressed in several structures, including adult brain; adult head; eye disc; inner photoreceptor cell; and presumptive embryonic/larval system. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See klg in Genome Data Viewer
Location:
94D3-94D4; 3-77 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22899284..22961731)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18725006..18787453)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43846 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46088 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43655 Neighboring gene Transition protein-like 94D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Long-term memory formation in Drosophila requires training-dependent glial transcription. Matsuno M, et al. J Neurosci, 2015 Apr 8. PMID 25855172, Free PMC Article
  2. The Drosophila cell adhesion molecule klingon is required for long-term memory formation and is regulated by Notch. Matsuno M, et al. Proc Natl Acad Sci U S A, 2009 Jan 6. PMID 19104051, Free PMC Article
  3. klingon, a novel member of the Drosophila immunoglobulin superfamily, is required for the development of the R7 photoreceptor neuron. Butler SJ, et al. Development, 1997 Feb. PMID 9043060
  4. Wrapper, a novel member of the Ig superfamily, is expressed by midline glia and is required for them to ensheath commissural axons in Drosophila. Noordermeer JN, et al. Neuron, 1998 Nov. PMID 9856456
  5. Transcription factor NF-Y is involved in differentiation of R7 photoreceptor cell in Drosophila. Yoshioka Y, et al. Biol Open, 2012 Jan 15. PMID 23213364, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables axon guidance receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in R7 cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in R7 cell fate commitment IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT involved_in anesthesia-resistant memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extrinsic component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
klingon
Names
CG6669-PA
klg-PA
ruslan

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22899284..22961731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079730.3 → NP_524454.2  klingon [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524454.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91670, Q9VCT4
    Related
    FBpp0083730
    Conserved Domains (5) summary
    cd00096
    Location:118 → 191
    Ig; Immunoglobulin domain
    smart00408
    Location:213 → 273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:109 → 195
    IG_like; Immunoglobulin like
    cd00063
    Location:392 → 486
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07114
    Location:63 → 124
    DUF1370; Protein of unknown function (DUF1370)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91670 P91670
Q9VCT4 Q9VCT4

Gene LinkOut

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