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cd cardinal [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42681, updated on 4-Jan-2025

Summary

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Official Symbol
cdprovided by FlyBase
Official Full Name
cardinalprovided by FlyBase
Primary source
FLYBASE:FBgn0263986
Locus tag
Dmel_CG6969
See related
AllianceGenome:FB:FBgn0263986
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6969; Dmel\CG6969; HPX6; PHS
Summary
Predicted to enable peroxidase activity. Involved in kynurenine metabolic process and ommochrome biosynthetic process. Located in lysosome. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in congenital hypothyroidism; glomerulonephritis; and thyroid dyshormonogenesis 2A. Orthologous to human TPO (thyroid peroxidase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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Location:
94C1-94C1; 3-76 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22694959..22697990)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18520681..18523712)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene wolfram syndrome 1 Neighboring gene Nucleoporin 133kD Neighboring gene Cytochrome P450 6d4 Neighboring gene Crustacean cardioactive peptide Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FURTHER GENETIC STUDIES OF THE SOUTH AMHERST POPULATION OF DROSOPHILA MELANOGASTER. Ives PT. Evolution, 1970 Sep. PMID 28562987
  2. 3-Hydroxykynurenine as a Potential Ligand for Hsp70 Proteins and Its Effects on Drosophila Memory After Heat Shock. Zhuravlev AV, et al. Mol Neurobiol, 2022 Mar. PMID 35029786
  3. 3-Hydroxykynurenine in Regulation of Drosophila Behavior: The Novel Mechanisms for Cardinal Phenotype Manifestations. Zhuravlev AV, et al. Front Physiol, 2020. PMID 32848886, Free PMC Article
  4. Enzymatic and non-enzymatic pathways of kynurenines' dimerization: the molecular factors for oxidative stress development. Zhuravlev AV, et al. PLoS Comput Biol, 2018 Dec. PMID 30532237, Free PMC Article
  5. cd(1) Mutation in Drosophila Affects Phenoxazinone Synthase Catalytic Site and Impairs Long-Term Memory. Zhuravlev AV, et al. Int J Mol Sci, 2022 Oct 15. PMID 36293213, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in kynurenine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ommochrome biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cardinal
Names
CG6969-PA
cd-PA
phenoxazinone synthase
phenoxazinone synthetase
NP_651081.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22694959..22697990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142824.3 → NP_651081.1  cardinal [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651081.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCW2
    Related
    FBpp0083696
    Conserved Domains (2) summary
    cd09823
    Location:364 → 750
    peroxinectin_like; peroxinectin_like animal heme peroxidases
    pfam03098
    Location:218 → 755
    An_peroxidase; Animal haem peroxidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCW2 Q9VCW2

Gene LinkOut

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