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loco locomotion defects [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42672, updated on 9-Dec-2024

Summary

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Official Symbol
locoprovided by FlyBase
Official Full Name
locomotion defectsprovided by FlyBase
Primary source
FLYBASE:FBgn0020278
Locus tag
Dmel_CG5248
See related
AllianceGenome:FB:FBgn0020278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17229; CG5248; dLoco; Dmel\CG5248; Loco; LOCO
Summary
Enables G-protein alpha-subunit binding activity; GDP-dissociation inhibitor activity; and GTPase activator activity. Involved in several processes, including nervous system development; oogenesis; and septate junction assembly. Located in apical cortex and plasma membrane. Is expressed in several structures, including epithelium; female germline cell; glial cell; head epidermis primordium; and sensory nervous system primordium. Orthologous to human RGS12 (regulator of G protein signaling 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See loco in Genome Data Viewer
Location:
94B6-94B8; 3-75 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22619968..22639387, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18445690..18465109, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosome recycling factor 2 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L45 Neighboring gene long non-coding RNA:CR43475 Neighboring gene antisense RNA:CR43474 Neighboring gene wide awake Neighboring gene Glutamate-cysteine ligase modifier subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and functional analysis of the Drosophila gene loco. Granderath S, et al. Methods Enzymol, 2004. PMID 15313576
  2. Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity. Mahajan A, et al. Am J Hum Genet, 2016 Sep 1. PMID 27588450, Free PMC Article
  3. The GoLoco motif: a Galphai/o binding motif and potential guanine-nucleotide exchange factor. Siderovski DP, et al. Trends Biochem Sci, 1999 Sep. PMID 10470031
  4. Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia in Drosophila. Schwabe T, et al. Biol Open, 2017 Feb 15. PMID 28108476, Free PMC Article
  5. Double suppression of the Gα protein activity by RGS proteins. Lin C, et al. Mol Cell, 2014 Feb 20. PMID 24560274

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The effects of the interaction of Rpd3 and Loco on longevity in D. melanogaster are reported.
    Title: Longer lifespan in the Rpd3 and Loco signaling results from the reduced catabolism in young age with noncoding RNA.
  2. RGS proteins, such as Loco, with with GTPase-activating protein (GAP) activity affect both stress resistance and longevity in several species.
    Title: Regulation of longevity by regulator of G-protein signaling protein, Loco.
  3. Rap/Fzr targets Loco for ubiquitination, thereby regulating glial differentiation in the developing nervous system.
    Title: Regulation of glia number in Drosophila by Rap/Fzr, an activator of the anaphase-promoting complex, and Loco, an RGS protein.
  4. specific isoforms of loco are required for the differentiation of the male gonad and genital disc
    Title: The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster.
  5. Loco was identified and a functional analysis made.
    Title: Identification and functional analysis of the Drosophila gene loco.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon ensheathment in central nervous system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal/ventral axis specification, ovarian follicular epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of glial blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heart process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ovarian nurse cell to oocyte transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of asymmetric cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in ventral cord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
locomotion defects
Names
CG5248-PB
CG5248-PC
CG5248-PD
CG5248-PF
CG5248-PH
loco-PB
loco-PC
loco-PD
loco-PF
loco-PH
locomotion defect

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22619968..22639387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170030.2 → NP_732773.1  locomotion defects, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732773.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NGQ0, Q9UB06, Q9VCX1, Q9XYX8
    Related
    FBpp0083666
    Conserved Domains (5) summary
    smart00455
    Location:1144 → 1213
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:1073 → 1145
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08706
    Location:828 → 941
    RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins
    cd00992
    Location:69 → 145
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:251 → 391
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

  2. NM_170032.3 → NP_732775.1  locomotion defects, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732775.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCX2
    Related
    FBpp0083668
    Conserved Domains (3) summary
    smart00455
    Location:778 → 847
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:707 → 779
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08706
    Location:462 → 575
    RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins

  3. NM_001260312.2 → NP_001247241.1  locomotion defects, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247241.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7N2
    Conserved Domains (3) summary
    smart00455
    Location:385 → 454
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:314 → 386
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08706
    Location:69 → 182
    RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins

  4. NM_170033.3 → NP_732776.1  locomotion defects, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732776.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IN00
    Related
    FBpp0083669
    Conserved Domains (3) summary
    smart00455
    Location:432 → 501
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:361 → 433
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08706
    Location:116 → 229
    RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins

  5. NM_001260311.1 → NP_001247240.1  locomotion defects, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247240.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5A7N8
    Conserved Domains (3) summary
    smart00455
    Location:449 → 518
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:378 → 450
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08706
    Location:133 → 246
    RGS_R12-like; Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7N2 A0A0B4K7N2
D5A7N8 D5A7N8
Q8IN00 Q8IN00
Q95SQ2 Q95SQ2
Q9VCX1.2 Q9VCX1
Q9VCX2 Q9VCX2

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