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tHMG1 testis-enriched HMG-box-containing protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42650, updated on 9-Dec-2024

Summary

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Official Symbol
tHMG1provided by FlyBase
Official Full Name
testis-enriched HMG-box-containing protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0038978
Locus tag
Dmel_CG7045
See related
AllianceGenome:FB:FBgn0038978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7045; Dmel\CG7045; thmg-1; tHMG-1
Summary
Predicted to enable transcription cis-regulatory region binding activity. Located in cytoplasm; nucleus; and polytene chromosome interband. Is expressed in male germline cell and testis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See tHMG1 in Genome Data Viewer
Location:
94B1-94B1; 3-75 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22491829..22492381)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18317551..18318103)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Prefoldin 5 Neighboring gene uncharacterized protein Neighboring gene Chaperonin containing TCP1 subunit 1 Neighboring gene testis-enriched HMG-box-containing protein 2 Neighboring gene Octopamine beta1 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The HMG-box-containing proteins tHMG-1 and tHMG-2 interact during the histone-to-protamine transition in Drosophila spermatogenesis. Gärtner SM, et al. Eur J Cell Biol, 2015 Jan. PMID 25464903
  2. High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in Drosophila. Ragab A, et al. Genetics, 2006 Feb. PMID 16299391, Free PMC Article
  3. A Testis-Specific Chaperone and the Chromatin Remodeler ISWI Mediate Repackaging of the Paternal Genome. Doyen CM, et al. Cell Rep, 2015 Nov 17. PMID 26549447
  4. Copper homeostasis gene discovery in Drosophila melanogaster. Norgate M, et al. Biometals, 2007 Jun. PMID 17216353
  5. Genome-Wide Mapping Targets of the Metazoan Chromatin Remodeling Factor NURF Reveals Nucleosome Remodeling at Enhancers, Core Promoters and Gene Insulators. Kwon SY, et al. PLoS Genet, 2016 Apr. PMID 27046080, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding, bending IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
testis-enriched HMG-box-containing protein 1
Names
CG7045-PA
tHMG1-PA
testis-enriched HMG-box-containing protein-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22491829..22492381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142798.2 → NP_651055.1  testis-enriched HMG-box-containing protein 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651055.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PV93, Q9VCZ5
    Related
    FBpp0083651
    Conserved Domains (2) summary
    cd01390
    Location:8 → 74
    HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
    pfam06501
    Location:55 → 116
    Herpes_U55; Human herpesvirus U55 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCZ5 Q9VCZ5

Gene LinkOut

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