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CG5377 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42645, updated on 4-Jan-2025

Summary

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Official Symbol
CG5377provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038974
Locus tag
Dmel_CG5377
See related
AllianceGenome:FB:FBgn0038974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5377
Summary
Enables serine hydrolase activity. Predicted to be located in mitochondrion. Is expressed in adult head; adult heart; and organism. Orthologous to human BPHL (biphenyl hydrolase like). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG5377 in Genome Data Viewer
Location:
94A16-94A16; 3-74 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22466905..22468157, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18292627..18293879, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylethanolamine-binding protein 1 Neighboring gene Neurexin 1 Neighboring gene mir-4952 stem loop Neighboring gene Prefoldin 5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mRNA transportome of the BicD/Egl transport machinery. Vazquez-Pianzola P, et al. RNA Biol, 2017 Jan 2. PMID 27801632, Free PMC Article
  2. Time-resolved mapping of genetic interactions to model rewiring of signaling pathways. Heigwer F, et al. Elife, 2018 Dec 28. PMID 30592458, Free PMC Article
  3. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
  4. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
  5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-amino-acid esterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables serine hydrolase activity HDA PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5377-PA
NP_651052.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22466905..22468157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142795.4 → NP_651052.1  uncharacterized protein Dmel_CG5377 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651052.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRU8, Q9VD00
    Related
    FBpp0083686
    Conserved Domains (2) summary
    COG0596
    Location:26 → 274
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:45 → 257
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRU8 Q8MRU8
Q9VD00 Q9VD00

Gene LinkOut

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