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PyK - Pyruvate kinase

Enables pyruvate kinase activity. Involved in glucose homeostasis; pyruvate metabolic process; and response to sucrose. Located in P granule and cytosol. Is expressed in several structures, including adult brain; adult head; adult heart; germline cell; and muscle cell. Used to study disease of metabolism. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R) and PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa