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Sar1 - Secretion-associated Ras-related 1

Enables scaffold protein binding activity. Involved in several processes, including COPII vesicle coating; chitin-based larval cuticle pattern formation; and positive regulation of cellular component organization. Acts upstream of with a positive effect on chitin-based cuticle development. Located in endoplasmic reticulum exit site. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gland; and gut section. Human ortholog(s) of this gene implicated in chylomicron retention disease. Orthologous to human SAR1A (secretion associated Ras related GTPase 1A) and SAR1B (secretion associated Ras related GTPase 1B). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa