Sar1 Secretion-associated Ras-related 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sar1provided by FlyBase
Official Full Name: Secretion-associated Ras-related 1provided by FlyBase
Primary source: FLYBASE:FBgn0038947
Locus tag: Dmel_CG7073
See related: AllianceGenome:FB:FBgn0038947
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5712; anon-EST:Liang-1.48; bro5; CG7073; clone 1.48; Dar-3; dar3; Dar3; Dm Sar1; Dmel\CG7073; dsar1; l(3)05712; NP_732719; Q95SY7; sar1; SAR1
Summary: Enables scaffold protein binding activity. Involved in several processes, including COPII vesicle coating; chitin-based larval cuticle pattern formation; and positive regulation of cellular component organization. Acts upstream of with a positive effect on chitin-based cuticle development. Located in endoplasmic reticulum exit site. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gland; and gut section. Human ortholog(s) of this gene implicated in chylomicron retention disease. Orthologous to human SAR1A (secretion associated Ras related GTPase 1A) and SAR1B (secretion associated Ras related GTPase 1B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 94A5-94A6; 3-74 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (22356685..22360711)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18182407..18186433)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Essential Role of COPII Proteins in Maintaining the Contractile Ring Anchoring to the Plasma Membrane during Cytokinesis in Drosophila Male Meiosis.
Title: Essential Role of COPII Proteins in Maintaining the Contractile Ring Anchoring to the Plasma Membrane during Cytokinesis in Drosophila Male Meiosis.
Kruppel-like factor Dar1 promotes dendrite growth in part by suppressing the expression of microtubule-severing protein Spastin.
Title: Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1.
dSec16 binds ER cups via its arginine-rich domain, interacts with Sar1-GTP that is generated on ER membrane by Sec12 and concentrates it in the ER cups where it initiates the formation of COPII vesicles
Title: Drosophila Sec16 mediates the biogenesis of tER sites upstream of Sar1 through an arginine-rich motif.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1886 (e-PCR)
- UniSTS:146

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in COPII vesicle coating	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based larval cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in larval chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral entry into host cell	HMP more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of COPII vesicle coating	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of COPII vesicle coating	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPII vesicle coat	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum exit site	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Secretion-associated Ras-related 1

Names: CG7073-PA; CG7073-PC; CG7073-PD; CG7073-PE; Sar1 ortholog; Sar1-PA; Sar1-PC; Sar1-PD; Sar1-PE; dendritic arbor reduction 3; sar1; secretion-associated RAS-related 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

22356685..22360711

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170001.3 → NP_732718.1 Secretion-associated Ras-related 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732718.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NFN8, Q9VD29

Related

FBpp0083607

Conserved Domains (1) summary

cd00879
Location:2 → 192

Sar1; Sar1 is an essential component of COPII vesicle coats
NM_170002.3 → NP_732719.1 Secretion-associated Ras-related 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732719.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NFN8, Q9VD29

Related

FBpp0083606

Conserved Domains (1) summary

cd00879
Location:2 → 192

Sar1; Sar1 is an essential component of COPII vesicle coats
NM_170000.3 → NP_732717.1 Secretion-associated Ras-related 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732717.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NFN8, Q9VD29

Related

FBpp0083604

Conserved Domains (1) summary

cd00879
Location:2 → 192

Sar1; Sar1 is an essential component of COPII vesicle coats
NM_206542.2 → NP_996265.1 Secretion-associated Ras-related 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996265.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NFN8, Q9VD29

Conserved Domains (1) summary

cd00879
Location:2 → 192

Sar1; Sar1 is an essential component of COPII vesicle coats