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Fancm Fanconi anemia group M helicase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42543, updated on 4-Jan-2025

Summary

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Official Symbol
Fancmprovided by FlyBase
Official Full Name
Fanconi anemia group M helicaseprovided by FlyBase
Primary source
FLYBASE:FBgn0038889
Locus tag
Dmel_CG7922
See related
AllianceGenome:FB:FBgn0038889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg7922; CG7922; Dmel\CG7922; fancm
Summary
Enables 3'-5' DNA helicase activity. Involved in DNA duplex unwinding; DNA recombination; and negative regulation of mitotic recombination. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 15 and spermatogenic failure 28. Orthologous to human FANCM (FA complementation group M). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Fancm in Genome Data Viewer
Location:
93E2-93E2; 3-72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21482325..21487444)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17308047..17313166)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ladybird early Neighboring gene long non-coding RNA:CR43453 Neighboring gene long non-coding RNA:CR44032 Neighboring gene C15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biochemical Activities and Genetic Functions of the Drosophila melanogaster Fancm Helicase in DNA Repair. Romero NE, et al. Genetics, 2016 Oct. PMID 27466228, Free PMC Article
  2. Division of Labor by the HELQ, BLM, and FANCM Helicases during Homologous Recombination Repair in Drosophila melanogaster. Thomas A, et al. Genes (Basel), 2022 Mar 8. PMID 35328029, Free PMC Article
  3. A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster. Yin H, et al. PLoS Genet, 2011 Dec. PMID 22194694, Free PMC Article
  4. A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. Kojima T, et al. Dev Biol, 2005 Mar 15. PMID 15733670
  5. Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases. Kuo HK, et al. Genetics, 2014 Nov. PMID 25205745, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3'-5' DNA helicase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 3'-5' DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables four-way junction helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via synthesis-dependent strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via synthesis-dependent strand annealing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mitotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in recombinational repair ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
fanconi anemia group M helicase
Names
CG7922-PA
CG7922-PB
Fancm-PA
Fancm-PB
fanconi anemia group M (FANCM) helicase
NP_001262806.1
NP_650971.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21482325..21487444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275877.1 → NP_001262806.1  fanconi anemia group M helicase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262806.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VDA0, R4SCI1
    Conserved Domains (4) summary
    COG1111
    Location:43 → 608
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd12091
    Location:269 → 378
    FANCM_ID; Insert domain of FANCM and related proteins
    pfam00271
    Location:417 → 539
    Helicase_C; Helicase conserved C-terminal domain
    pfam04851
    Location:55 → 221
    ResIII; Type III restriction enzyme, res subunit

  2. NM_142714.3 → NP_650971.2  fanconi anemia group M helicase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650971.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VDA0, R4SCI1
    Conserved Domains (4) summary
    COG1111
    Location:43 → 608
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd12091
    Location:269 → 378
    FANCM_ID; Insert domain of FANCM and related proteins
    pfam00271
    Location:417 → 539
    Helicase_C; Helicase conserved C-terminal domain
    pfam04851
    Location:55 → 221
    ResIII; Type III restriction enzyme, res subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VDA0 Q9VDA0
Q9VDA0.2

Gene LinkOut

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