U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tbc1d22 TBC1 domain family member 22 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42498, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Tbc1d22provided by FlyBase
Official Full Name
TBC1 domain family member 22provided by FlyBase
Primary source
FLYBASE:FBgn0038855
Locus tag
Dmel_CG5745
See related
AllianceGenome:FB:FBgn0038855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5745; Dmel\CG5745; dTBC1D22
Summary
Enables GTPase activator activity. Located in cytosol. Is expressed in organism. Orthologous to human TBC1D22A (TBC1 domain family member 22A) and TBC1D22B (TBC1 domain family member 22B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tbc1d22 in Genome Data Viewer
Location:
93B12-93B12; 3-70 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21102199..21105113)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16927921..16930835)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein at 93B Neighboring gene long non-coding RNA:CR44178 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46045 Neighboring gene Secretory 15 Neighboring gene tetracycline resistance Neighboring gene Rab11

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Mehta SQ, et al. Neuron, 2005 Apr 21. PMID 15848801
  2. Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy. Duan X, et al. Cell Rep, 2021 Aug 31. PMID 34469730
  3. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
  4. Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency. Cheli VT, et al. Hum Mol Genet, 2010 Mar 1. PMID 20015953, Free PMC Article
  5. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.
    Title: Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
TBC1 domain family member 22
Names
CG5745-PA
Tbc1d22-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21102199..21105113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142684.3 → NP_650941.3  TBC1 domain family member 22 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650941.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RC5, Q9VDE7
    Related
    FBpp0083411
    Conserved Domains (1) summary
    smart00164
    Location:243 → 496
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95RC5 Q95RC5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools