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DVL2 dishevelled segment polarity protein 2 [ Gallus gallus (chicken) ]

Gene ID: 424949, updated on 3-Dec-2024

Summary

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Symbol
DVL2provided by CGNC
Full Name
dishevelled segment polarity protein 2provided by CGNC
Primary source
CGNC:6376
See related
Ensembl:ENSGALG00010017773
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
DVL3
Orthologs
human mouse all
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Genomic context

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See DVL2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (15488769..15516254)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (15282598..15310056)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054095 Neighboring gene ATP binding cassette subfamily C member 5 Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon Neighboring gene adaptor related protein complex 2 mu 1 subunit Neighboring gene ATP binding cassette subfamily F member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables frizzled binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
segment polarity protein dishevelled homolog DVL-3
Names
dishevelled segment polarity protein 3
dishevelled, dsh homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    15488769..15516254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015291563.4 → XP_015147049.2  segment polarity protein dishevelled homolog DVL-3 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z2Y5
    Conserved Domains (3) summary
    smart00021
    Location:3 → 84
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:248 → 335
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:429 → 512
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

  2. XM_015291562.4 → XP_015147048.1  segment polarity protein dishevelled homolog DVL-3 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z2Y5
    Related
    ENSGALP00010025439.1, ENSGALT00010042949.1
    Conserved Domains (5) summary
    smart00021
    Location:3 → 84
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:248 → 335
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:431 → 514
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:89 → 246
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:518 → 719
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  3. XM_015291566.4 → XP_015147052.1  segment polarity protein dishevelled homolog DVL-3 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z2Y5
    Related
    ENSGALP00010025443.1, ENSGALT00010042953.1
    Conserved Domains (5) summary
    smart00021
    Location:3 → 84
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:248 → 335
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:414 → 497
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:89 → 246
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:501 → 702
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  4. XM_046898841.1 → XP_046754797.1  segment polarity protein dishevelled homolog DVL-3 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZAF1

  5. XM_040705691.1 → XP_040561625.1  segment polarity protein dishevelled homolog DVL-3 isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZAF1
    Conserved Domains (3) summary
    cd00992
    Location:194 → 281
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:377 → 460
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    cl02426
    Location:3 → 30
    DIX; DIX domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    15282598..15310056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040678743.2 → XP_040534677.1  segment polarity protein dishevelled homolog DVL-3 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z2Y5
    Conserved Domains (5) summary
    smart00021
    Location:3 → 84
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:248 → 335
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:429 → 512
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:89 → 246
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:516 → 717
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  2. XM_040678747.2 → XP_040534681.1  segment polarity protein dishevelled homolog DVL-3 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z2Y5
    Conserved Domains (5) summary
    smart00021
    Location:3 → 84
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:248 → 335
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:431 → 514
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:89 → 246
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:518 → 719
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  3. XM_040678744.2 → XP_040534678.1  segment polarity protein dishevelled homolog DVL-3 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z2Y5
    Conserved Domains (5) summary
    smart00021
    Location:3 → 84
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:248 → 335
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:414 → 497
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:89 → 246
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:501 → 702
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  4. XM_046924384.1 → XP_046780340.1  segment polarity protein dishevelled homolog DVL-3 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZAF1

  5. XM_040678746.1 → XP_040534680.1  segment polarity protein dishevelled homolog DVL-3 isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZAF1
    Conserved Domains (3) summary
    cd00992
    Location:194 → 281
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:377 → 460
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    cl02426
    Location:3 → 30
    DIX; DIX domain
Nucleotide Protein Strain
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