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CG17271 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42463, updated on 4-Jan-2025

Summary

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Official Symbol
CG17271provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038829
Locus tag
Dmel_CG17271
See related
AllianceGenome:FB:FBgn0038829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG17271; Dm_3R:88623
Summary
Predicted to enable calcium ion binding activity. Involved in sexual reproduction. Predicted to be located in extracellular space. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal epidermis primordium; embryonic dorsal epidermis; and gland. Orthologous to human MCFD2 (multiple coagulation factor deficiency 2, ER cargo receptor complex subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG17271 in Genome Data Viewer
Location:
93A1-93A1; 3-69 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20819129..20821848, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16644851..16647570, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Fancd2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila oocyte proteome composition covaries with female mating status. McDonough-Goldstein CE, et al. Sci Rep, 2021 Feb 4. PMID 33542461, Free PMC Article
  2. A genetic screen in Drosophila for regulators of human prostate cancer progression. Ito S, et al. Biochem Biophys Res Commun, 2014 Sep 5. PMID 25117438
  3. Drep-2 is a novel synaptic protein important for learning and memory. Andlauer TF, et al. Elife, 2014 Nov 13. PMID 25392983, Free PMC Article
  4. Seminal influences: Drosophila Acps and the molecular interplay between males and females during reproduction. Ravi Ram K, et al. Integr Comp Biol, 2007 Sep. PMID 21672851
  5. Contribution of Orb2A stability in regulated amyloid-like oligomerization of Drosophila Orb2. White-Grindley E, et al. PLoS Biol, 2014 Feb. PMID 24523662, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISM
Inferred from Sequence Model
more info
  
Process Evidence Code Pubs
involved_in sexual reproduction IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG17271-PA
CG17271-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20819129..20821848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001043269.3 → NP_001036734.1  uncharacterized protein Dmel_CG17271, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036734.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1A6Y2, Q0KI39
    Conserved Domains (1) summary
    pfam13499
    Location:174 → 262
    EF-hand_7; EF-hand domain pair

  2. NM_142659.2 → NP_650916.1  uncharacterized protein Dmel_CG17271, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650916.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZH7, Q9VDI5
    Related
    FBpp0083397
    Conserved Domains (2) summary
    pfam13499
    Location:174 → 250
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:174 → 250
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KI39 Q0KI39
Q8MZH7 Q8MZH7
Q9VDI5 Q9VDI5

Gene LinkOut

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