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Srp72 Signal recognition particle 72 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42439, updated on 4-Jan-2025

Summary

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Official Symbol
Srp72provided by FlyBase
Official Full Name
Signal recognition particle 72provided by FlyBase
Primary source
FLYBASE:FBgn0038810
Locus tag
Dmel_CG5434
See related
AllianceGenome:FB:FBgn0038810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5434; Dmel\CG5434; SRP72
Summary
Predicted to enable 7S RNA binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in adult head and adult heart. Orthologous to human SRP72 (signal recognition particle 72). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Srp72 in Genome Data Viewer
Location:
92F2-92F2; 3-69 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20588711..20591040)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16414433..16416762)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46044 Neighboring gene Septin 2 Neighboring gene Pseudouridine synthase 1 Neighboring gene bonus Neighboring gene transfer RNA:Leucine-TAA 1-1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article
  2. Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling. Schroeder AM, et al. PLoS Genet, 2022 Oct. PMID 36240221, Free PMC Article
  3. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. Fox RM, et al. J Cell Biol, 2010 Nov 1. PMID 21041443, Free PMC Article
  4. CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. Abrams EW, et al. Development, 2005 Jun. PMID 15901661
  5. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Saleh MC, et al. Nat Cell Biol, 2006 Aug. PMID 16862146, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 7S RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 7S RNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of signal recognition particle IEA
Inferred from Electronic Annotation
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
signal recognition particle 72
Names
CG5434-PA
Srp72-PA
signal recognition particle protein 72

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20588711..20591040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142641.3 → NP_650898.1  signal recognition particle 72 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650898.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BHY9, Q9VDK7
    Related
    FBpp0083319
    Conserved Domains (4) summary
    sd00006
    Location:45 → 71
    TPR; TPR repeat [structural motif]
    pfam08492
    Location:534 → 583
    SRP72; SRP72 RNA-binding domain
    pfam12895
    Location:24 → 101
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam17004
    Location:52 → 155
    SRP_TPR_like; Putative TPR-like repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BHY9 Q5BHY9
Q95SX0 Q95SX0
Q9VDK7 Q9VDK7

Gene LinkOut

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