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Srp14 Signal recognition particle 14 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42436, updated on 4-Jan-2025

Summary

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Official Symbol
Srp14provided by FlyBase
Official Full Name
Signal recognition particle 14provided by FlyBase
Primary source
FLYBASE:FBgn0038808
Locus tag
Dmel_CG5417
See related
AllianceGenome:FB:FBgn0038808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE48595; CG5417; Dmel\CG5417; SRP14
Summary
Predicted to enable 7S RNA binding activity and endoplasmic reticulum signal peptide binding activity. Predicted to be involved in protein targeting to ER. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in organism. Orthologous to human SRP14 (signal recognition particle 14). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Srp14 in Genome Data Viewer
Location:
92F2-92F2; 3-69 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20580115..20580764)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16405837..16406486)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Elongin B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Septin 2 Neighboring gene antisense RNA:CR46044

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling. Schroeder AM, et al. PLoS Genet, 2022 Oct. PMID 36240221, Free PMC Article
  2. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
  3. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. Fox RM, et al. J Cell Biol, 2010 Nov 1. PMID 21041443, Free PMC Article
  4. CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. Abrams EW, et al. Development, 2005 Jun. PMID 15901661
  5. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Lee KH, et al. Cell, 2016 Oct 20. PMID 27768896, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 7S RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables endoplasmic reticulum signal peptide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
signal recognition particle 14
Names
CG5417-PB
Srp14-PB
signal recognition particle protein 14

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20580115..20580764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142639.4 → NP_650896.2  signal recognition particle 14 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650896.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAA2, Q9VDL0
    Conserved Domains (1) summary
    pfam02290
    Location:4 → 94
    SRP14; Signal recognition particle 14kD protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IGQ4 Q8IGQ4
Q9VDL0 Q9VDL0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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