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Orp8 Oxysterol-binding protein-related protein 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42412, updated on 9-Dec-2024

Summary

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Official Symbol
Orp8provided by FlyBase
Official Full Name
Oxysterol-binding protein-related protein 8provided by FlyBase
Primary source
FLYBASE:FBgn0261550
Locus tag
Dmel_CG42668
See related
AllianceGenome:FB:FBgn0261550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15684; CG42668; CG5077; Dmel\CG42668
Old locus tag
Dmel_CG15684; Dmel_CG5077
Summary
Predicted to enable cholesterol binding activity and phospholipid transporter activity. Predicted to be involved in phospholipid transport. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and membrane. Is expressed in several structures, including adult fat body; adult head; embryonic/larval midgut primordium; germline cell; and gut section. Orthologous to human OSBPL5 (oxysterol binding protein like 5) and OSBPL8 (oxysterol binding protein like 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Orp8 in Genome Data Viewer
Location:
92E2-92E2; 3-68 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20309344..20324196)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16135066..16149918)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45800 Neighboring gene uncharacterized protein Neighboring gene Sirtuin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia. Byrne DJ, et al. Acta Neuropathol Commun, 2022 Mar 28. PMID 35346366, Free PMC Article
  2. Case studies of ends-out gene targeting in Drosophila. Chen H, et al. Genesis, 2009 May. PMID 19298016
  3. OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila. Ma Z, et al. Development, 2010 Nov. PMID 20943709
  4. Sex-specific pharmacokinetic response to phytoestrogens in Drosophila melanogaster. Sadova N, et al. Biomed Pharmacother, 2024 Jun. PMID 38663102
  5. GATAe-dependent and -independent expressions of genes in the differentiated endodermal midgut of Drosophila. Okumura T, et al. Gene Expr Patterns, 2007 Jan. PMID 16914392

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in phospholipid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Oxysterol-binding protein-related protein 8
Names
CG42668-PD
CG42668-PE
CG42668-PF
CG42668-PG
CG42668-PH
CG42668-PK
CG42668-PL
CG42668-PM
CG42668-PN
Orp8-PD
Orp8-PE
Orp8-PF
Orp8-PG
Orp8-PH
Orp8-PK
Orp8-PL
Orp8-PM
Orp8-PN
oxysterol-binding protein-related protein 8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20309344..20324196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202322.2 → NP_001189251.1  Oxysterol-binding protein-related protein 8, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189251.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDG2, C6TPA8
    Conserved Domains (4) summary
    cd00890
    Location:815 → 909
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cd13286
    Location:197 → 327
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:204 → 322
    PH; PH domain
    pfam01237
    Location:437 → 762
    Oxysterol_BP; Oxysterol-binding protein

  2. NM_001202321.3 → NP_001189250.2  Oxysterol-binding protein-related protein 8, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189250.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JCZ0, C6TPA8
    Conserved Domains (4) summary
    cd00890
    Location:849 → 943
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cd13286
    Location:231 → 361
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:238 → 356
    PH; PH domain
    pfam01237
    Location:471 → 796
    Oxysterol_BP; Oxysterol-binding protein

  3. NM_001202323.2 → NP_001189252.1  Oxysterol-binding protein-related protein 8, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189252.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDG2, C6TPA8
    Conserved Domains (4) summary
    cd00890
    Location:815 → 909
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cd13286
    Location:197 → 327
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:204 → 322
    PH; PH domain
    pfam01237
    Location:437 → 762
    Oxysterol_BP; Oxysterol-binding protein

  4. NM_001144614.2 → NP_001138086.1  Oxysterol-binding protein-related protein 8, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138086.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0M9, C6TPA8
    Conserved Domains (3) summary
    cd13286
    Location:57 → 187
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:64 → 182
    PH; PH domain
    pfam01237
    Location:438 → 763
    Oxysterol_BP; Oxysterol-binding protein

  5. NM_142621.6 → NP_650878.4  Oxysterol-binding protein-related protein 8, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650878.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TPA8, Q9I7I8
    Conserved Domains (3) summary
    cd13286
    Location:57 → 187
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:64 → 182
    PH; PH domain
    pfam01237
    Location:297 → 622
    Oxysterol_BP; Oxysterol-binding protein

  6. NM_169892.5 → NP_732499.4  Oxysterol-binding protein-related protein 8, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732499.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QP47, Q8IN56, Q961G0
    Conserved Domains (3) summary
    cd13286
    Location:57 → 187
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:64 → 182
    PH; PH domain
    pfam01237
    Location:288 → 604
    Oxysterol_BP; Oxysterol-binding protein

  7. NM_169893.4 → NP_732500.5  Oxysterol-binding protein-related protein 8, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732500.5

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TPA8, Q7KSB3
    Conserved Domains (3) summary
    cd13286
    Location:58 → 188
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:65 → 183
    PH; PH domain
    pfam01237
    Location:439 → 764
    Oxysterol_BP; Oxysterol-binding protein

  8. NM_001202320.2 → NP_001189249.2  Oxysterol-binding protein-related protein 8, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189249.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDD8, C6TPA8
    Conserved Domains (3) summary
    cd13286
    Location:58 → 188
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:65 → 183
    PH; PH domain
    pfam01237
    Location:298 → 623
    Oxysterol_BP; Oxysterol-binding protein

  9. NM_169894.4 → NP_732501.1  Oxysterol-binding protein-related protein 8, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732501.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NP7, Q8IN55
    Related
    FBpp0291806
    Conserved Domains (1) summary
    pfam01237
    Location:106 → 431
    Oxysterol_BP; Oxysterol-binding protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JCZ0 A0A0B4JCZ0
A0A0B4JDD8 A0A0B4JDD8
A0A0B4JDG2 A0A0B4JDG2
B7Z0M9 B7Z0M9
Q7KSB3 Q7KSB3
Q8IN55 Q8IN55
Q8IN56 Q8IN56
Q9I7I8 Q9I7I8

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