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Acsx2 Acyl-CoA synthetase X2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42353, updated on 4-Jan-2025

Summary

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Official Symbol
Acsx2provided by FlyBase
Official Full Name
Acyl-CoA synthetase X2provided by FlyBase
Primary source
FLYBASE:FBgn0038732
Locus tag
Dmel_CG11391
See related
AllianceGenome:FB:FBgn0038732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11391; Dmel\CG11391
Summary
Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Acsx2 in Genome Data Viewer
Location:
92B2-92B2; 3-67 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19778750..19780727)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15604472..15606449)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glutamate-gated chloride channel subunit alpha Neighboring gene Acyl-CoA synthetase X1 L Neighboring gene Acyl-CoA synthetase X1 R Neighboring gene Acyl-CoA synthetase X3 Neighboring gene Acyl-CoA synthetase X4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A tandem duplication in Drosophila melanogaster shows enhanced expression beyond the gene copy number. Loehlin DW, et al. Genetics, 2022 Mar 3. PMID 35100388, Free PMC Article
  2. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, et al. J Lipid Res, 2007 Dec. PMID 17762044
  3. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
  4. Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster. Wicker-Thomas C, et al. J Lipid Res, 2015 Nov. PMID 26353752, Free PMC Article
  5. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. Palu RA, et al. PLoS Genet, 2016 Apr. PMID 27058248, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Acyl-CoA synthetase X2
Names
Acsx2-PA
CG11391-PA
NP_650830.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19778750..19780727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142573.3 → NP_650830.1  Acyl-CoA synthetase X2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650830.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4V5Z0, Q9VDU2
    Related
    FBpp0083203
    Conserved Domains (2) summary
    COG0318
    Location:24 → 541
    CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    cl17068
    Location:51 → 527
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VDU2 Q9VDU2

Gene LinkOut

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