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subdued subdued [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42340, updated on 4-Jan-2025

Summary

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Official Symbol
subduedprovided by FlyBase
Official Full Name
subduedprovided by FlyBase
Primary source
FLYBASE:FBgn0038721
Locus tag
Dmel_CG16718
See related
AllianceGenome:FB:FBgn0038721
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG16718; Dmel\CG16718; Subdued
Summary
Enables monoatomic ion channel activity and phospholipid scramblase activity. Involved in several processes, including chloride transport; defense response to Gram-negative bacterium; and detection of temperature stimulus involved in sensory perception. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult proventriculus; central nervous system; epithelial tube; and larval multidendritic neurons. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to several human genes including ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See subdued in Genome Data Viewer
Location:
92A11-92A11; 3-66 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19633418..19642722, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15459140..15468444, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-9373 stem loop Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 13kD subunit Neighboring gene Nucleoporin 58kD

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila bestrophin-1 currents are regulated by phosphorylation via a CaMKII dependent mechanism. Duran C, et al. PLoS One, 2013. PMID 23554946, Free PMC Article
  2. Subdued, a TMEM16 family Ca²⁺-activated Cl⁻channel in Drosophila melanogaster with an unexpected role in host defense. Wong XM, et al. Elife, 2013 Nov 5. PMID 24192034, Free PMC Article
  3. Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids. Le T, et al. J Biol Chem, 2019 Mar 22. PMID 30700552, Free PMC Article
  4. The anoctamin family channel subdued mediates thermal nociception in Drosophila. Jang W, et al. J Biol Chem, 2015 Jan 23. PMID 25505177, Free PMC Article
  5. Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila. Himmel NJ, et al. Elife, 2023 Jan 23. PMID 36688373, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium-activated cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables intracellularly calcium-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellularly calcium-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellularly calcium-gated chloride channel activity TAS
Traceable Author Statement
more info
 PubMed 
enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of cold stimulus involved in thermoception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of temperature stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in plasma membrane phospholipid scrambling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
subdued
Names
CG16718-PA
CG16718-PB
CG16718-PD
CG16718-PE
CG16718-PF
subdued-PA
subdued-PB
subdued-PD
subdued-PE
subdued-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19633418..19642722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142563.2 → NP_650820.1  subdued, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650820.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P24, Q9VDV4
    Related
    FBpp0083215
    Conserved Domains (2) summary
    pfam04547
    Location:407 → 983
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:186 → 404
    Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

  2. NM_001202319.2 → NP_001189248.1  subdued, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189248.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JCY1, Q86P24
    Conserved Domains (2) summary
    pfam04547
    Location:431 → 1007
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:186 → 428
    Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

  3. NM_169867.3 → NP_732439.1  subdued, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732439.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P24, Q8IN71
    Related
    FBpp0083216
    Conserved Domains (2) summary
    pfam04547
    Location:258 → 834
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:37 → 255
    Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

  4. NM_001275808.1 → NP_001262737.1  subdued, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262737.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGH4, Q86P24
    Conserved Domains (2) summary
    pfam04547
    Location:282 → 858
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:37 → 279
    Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

  5. NM_001275807.1 → NP_001262736.1  subdued, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262736.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P24, Q8IN71
    Conserved Domains (2) summary
    pfam04547
    Location:258 → 834
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:37 → 255
    Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JCY1 A0A0B4JCY1
A0A0B4KGH4 A0A0B4KGH4
Q86P24 Q86P24
Q8IN71 Q8IN71
Q9VDV4 Q9VDV4

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