sqz squeeze [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sqzprovided by FlyBase
Official Full Name: squeezeprovided by FlyBase
Primary source: FLYBASE:FBgn0010768
Locus tag: Dmel_CG5557
See related: AllianceGenome:FB:FBgn0010768
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.697; CG5557; Dmel\CG5557; l(3)02102; Sqz; SQZ
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dendrite guidance and neuroblast development. Is expressed in several structures, including Leucokinin neurons; anterior-posterior subdivision of organism; apterous-expressing neuron of the lateral cluster of the thorax; central nervous system; and ganglia. Orthologous to human ZNF362 (zinc finger protein 362) and ZNF384 (zinc finger protein 384). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (19164211..19170576)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14989933..14996298)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Sqz appears to be a regulatory factor for neuropeptidergic identity common to all leucokinergic cells, whose function in different cell types is regulated by cell-specific factors.
Title: Squeeze involvement in the specification of Drosophila leucokinergic neurons: Different regulatory mechanisms endow the same neuropeptide selection.
Squeeze and Rotund are regulated by Nab and have roles in Drosophila development
Title: Nab controls the activity of the zinc-finger transcription factors Squeeze and Rotund in Drosophila development.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in dendrite guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain