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NP15.6 NP15.6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42282, updated on 4-Jan-2025

Summary

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Official Symbol
NP15.6provided by FlyBase
Official Full Name
NP15.6provided by FlyBase
Primary source
FLYBASE:FBgn0027785
Locus tag
Dmel_CG6008
See related
AllianceGenome:FB:FBgn0027785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.281; CG6008; Dmel\CG6008; dNDUFB11; ND-15.6; NDUFB11
Summary
Predicted to be involved in respiratory electron transport chain. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 3 and nuclear type mitochondrial complex I deficiency 30. Orthologous to human NDUFB11 (NADH:ubiquinone oxidoreductase subunit B11). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See NP15.6 in Genome Data Viewer
Location:
91E4-91E4; 3-65 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19027368..19028015)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14853090..14853737)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutamyl-tRNA amidotransferase, subunit A Neighboring gene Pyrroline 5-carboyxlate reductase Neighboring gene Prp18 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extraordinarily high density of unrelated genes showing overlapping and intraintronic transcription units. Misener SR, et al. Biochim Biophys Acta, 2000 Jun 21. PMID 10858562
  2. Mutations in the Drosophila mitochondrial tRNA amidotransferase, bene/gatA, cause growth defects in mitotic and endoreplicating tissues. Morris JZ, et al. Genetics, 2008 Feb. PMID 18245325, Free PMC Article
  3. The mitochondrial ribosomal protein mRpL4 regulates Notch signaling. Mo D, et al. EMBO Rep, 2023 Jun 5. PMID 37009823, Free PMC Article
  4. Senescent glia link mitochondrial dysfunction and lipid accumulation. Byrns CN, et al. Nature, 2024 Jun. PMID 38839958, Free PMC Article
  5. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
involved_in respiratory electron transport chain ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
 PubMed 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NP15.6
Names
CG6008-PA
NP15.6-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19027368..19028015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142517.3 → NP_650774.1  NP15.6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650774.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3L7
    Related
    FBpp0083126
    Conserved Domains (1) summary
    pfam10183
    Location:36 → 121
    ESSS; ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3L7 Q9V3L7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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