Vha100-2 Vacuolar H[+] ATPase 100kD subunit 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vha100-2provided by FlyBase
Official Full Name: Vacuolar H[+] ATPase 100kD subunit 2provided by FlyBase
Primary source: FLYBASE:FBgn0028670
Locus tag: Dmel_CG18617
See related: AllianceGenome:FB:FBgn0028670
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.296; BcDNA:LD21735; CG18617; CG7679; Dmel\CG18617; V100-2; vha100-2
Summary: Predicted to enable ATPase binding activity. Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport and vacuolar acidification. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including adult copper cell; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; and renal tubular acidosis. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1) and ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 91A5-91A5; 3-63 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18390323..18399169, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14216045..14224891, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to proton-transporting ATPase activity, rotational mechanism	IC Inferred by Curator more info	PubMed
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATPase activity, rotational mechanism	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of plasma membrane proton-transporting V-type ATPase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of vacuolar proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: vacuolar H[+] ATPase 100kD subunit 2

Names: CG18617-PA; CG18617-PB; Vha100-2-PA; Vha100-2-PB; vacuolar H + ATPase subunit 100-2; vacuolar H[+] ATPase subunit 100-2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

18390323..18399169 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142465.2 → NP_650722.1 vacuolar H[+] ATPase 100kD subunit 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650722.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VE75, Q9VE76, Q9XZ27

Related

FBpp0083071

Conserved Domains (2) summary

COG1269
Location:35 → 825

NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

pfam01496
Location:28 → 824

V_ATPase_I; V-type ATPase 116kDa subunit family
NM_169810.2 → NP_732337.1 vacuolar H[+] ATPase 100kD subunit 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732337.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VE75, Q9VE76, Q9XZ27

Related

FBpp0083072

Conserved Domains (2) summary

COG1269
Location:35 → 825

NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

pfam01496
Location:28 → 824

V_ATPase_I; V-type ATPase 116kDa subunit family