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Ssdp Sequence-specific single-stranded DNA-binding protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42177, updated on 9-Dec-2024

Summary

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Official Symbol
Ssdpprovided by FlyBase
Official Full Name
Sequence-specific single-stranded DNA-binding proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0011481
Locus tag
Dmel_CG7187
See related
AllianceGenome:FB:FBgn0011481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7187; Dmel\CG7187; l(3)neo48; ssdp
Summary
Enables sequence-specific single stranded DNA binding activity. Involved in embryonic pattern specification; positive regulation of canonical Wnt signaling pathway; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; ganglia; and mesoderm. Used to study autism spectrum disorder. Orthologous to several human genes including SSBP2 (single stranded DNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ssdp in Genome Data Viewer
Location:
90F6-90F7; 3-62 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18192494..18199595, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14018216..14025317, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Actin-related protein 5 Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 17 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster. Salim S, et al. PLoS Biol, 2023 Jul. PMID 37486945, Free PMC Article
  2. Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo. van Meyel DJ, et al. Development, 2003 May. PMID 12642495
  3. Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development. Chen L, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12381786, Free PMC Article
  4. The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. de Navascués J, et al. Mech Dev, 2010 Sep-Dec. PMID 20580820
  5. The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3. Gajan A, et al. Epigenetics Chromatin, 2016. PMID 26848313, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster.
    Title: The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster.
  2. The authors use a proteomics approach to discover the Chip/LDB-SSDP (ChiLS) complex as the ligand specifically binding to NPF motif of Pygo proteins.
    Title: An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c18196895-18196700 mobile_element_type = transposon:HMS-Beagle{}4853

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables sequence-specific single stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sequence-specific single-stranded DNA-binding protein
Names
CG7187-PA
CG7187-PB
CG7187-PC
CG7187-PD
Sequence-specific single-strand DNA-binding protein
Ssdp-PA
Ssdp-PB
Ssdp-PC
Ssdp-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18192494..18199595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169794.2 → NP_732304.1  Sequence-specific single-stranded DNA-binding protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732304.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VUZ9, Q8MZ49, Q9VEB9
    Related
    FBpp0083032
    Conserved Domains (1) summary
    pfam04503
    Location:81 → 393
    SSDP; Single-stranded DNA binding protein, SSDP

  2. NM_001275769.1 → NP_001262698.1  Sequence-specific single-stranded DNA-binding protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262698.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGW6, C8VUZ9, Q8MZ49
    Conserved Domains (1) summary
    pfam04503
    Location:81 → 393
    SSDP; Single-stranded DNA binding protein, SSDP

  3. NM_169795.1 → NP_732305.1  Sequence-specific single-stranded DNA-binding protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732305.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VUZ9, Q8MZ49, Q9VEB9
    Related
    FBpp0083033, FBtr0083613
    Conserved Domains (1) summary
    pfam04503
    Location:81 → 393
    SSDP; Single-stranded DNA binding protein, SSDP

  4. NM_142431.1 → NP_650688.1  Sequence-specific single-stranded DNA-binding protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650688.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VUZ9, Q8MZ49, Q9VEB9
    Related
    FBpp0083031, FBtr0083611
    Conserved Domains (1) summary
    pfam04503
    Location:81 → 393
    SSDP; Single-stranded DNA binding protein, SSDP
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGW6 A0A0B4KGW6
Q8MZ49 Q8MZ49
Q9VEB9 Q9VEB9

Gene LinkOut

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