cdm cadmus [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cdmprovided by FlyBase
Official Full Name: cadmusprovided by FlyBase
Primary source: FLYBASE:FBgn0261532
Locus tag: Dmel_CG7212
See related: AllianceGenome:FB:FBgn0261532
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3R23; Cdm; CG 7212; CG7212; Dmel\CG7212; imp13; Imp13; sd-5
Summary: Predicted to enable small GTPase binding activity. Involved in modulation of chemical synaptic transmission; neuron-neuron synaptic transmission; and phototaxis. Predicted to be active in cytoplasm. Is expressed in larval brain; larval somatic muscle cell; larval ventral nerve cord; organism; and spermatozoon. Orthologous to human IPO13 (importin 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18179275..18183479, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14004997..14009201, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Imp13 forms a ring-like molecule encircling the Mago-Y14 cargo with a conserved interaction surface.
Title: Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13.
Imp13 is a novel factor that affects neurotransmitter release at the fly neuromuscular junction.
Title: Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron-neuron synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

Names: CG7212-PA; CG7212-PB; cdm-PA; cdm-PB; complementation group 5; importin 13; importin-13; sd-5

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The following sections contain reference sequences that belong to a specific genome build. Explain