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htl - heartless

Enables transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including formation of primary germ layer; gliogenesis; and larval development. Acts upstream of with a positive effect on glial cell projection elongation. Located in postsynapse of neuromuscular junction. Is active in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; glial cell; larval sheath cell of ovary; muscle cell; and trunk visceral muscle primordium. Used to study high grade glioma. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to several human genes including FGFR1 (fibroblast growth factor receptor 1); FGFR2 (fibroblast growth factor receptor 2); and FGFR3 (fibroblast growth factor receptor 3). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to htl

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Species Gene Architecture aa