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CG43102 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42137, updated on 9-Dec-2024

Summary

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Official Symbol
CG43102provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0262562
Locus tag
Dmel_CG43102
See related
AllianceGenome:FB:FBgn0262562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ARHGEF17; CG14318; CG7397; Dmel\CG43102
Old locus tag
Dmel_CG14318; Dmel_CG7397
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization and positive regulation of Rho protein signal transduction. Predicted to be active in cytoplasm. Is expressed in leg joint; primary tracheal branch; and spermatozoon. Orthologous to human ARHGEF17 (Rho guanine nucleotide exchange factor 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG43102 in Genome Data Viewer
Location:
90C3-90C5; 3-61 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17768272..17794490, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13593994..13620212, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tyramine receptor II Neighboring gene Tyramine receptor Neighboring gene pasiflora 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genetic basis of variation in Drosophila melanogaster mating behavior. Yamamoto A, et al. iScience, 2024 May 17. PMID 38766354, Free PMC Article
  2. Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila. Jackson JA, et al. Curr Biol, 2024 May 20. PMID 38688282,
  3. Adult Drosophila sensory neurons specify dendritic territories independently of dendritic contacts through the Wnt5-Drl signaling pathway. Yasunaga K, et al. Genes Dev, 2015 Aug 15. PMID 26302791, Free PMC Article
  4. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article
  5. Cadmium-induced genome-wide DNA methylation changes in growth and oxidative metabolism in Drosophila melanogaster. Guan DL, et al. BMC Genomics, 2019 May 9. PMID 31072326, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG43102-PA
CG43102-PB
CG43102-PC
CG43102-PD
CG43102-PE
CG43102-PF
CG43102-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17768272..17794490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260226.2 → NP_001247155.1  uncharacterized protein Dmel_CG43102, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247155.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEF7
    Conserved Domains (2) summary
    pfam00621
    Location:1505 → 1687
    RhoGEF; RhoGEF domain
    cl17171
    Location:1679 → 1818
    PH-like; Pleckstrin homology-like domain

  2. NM_001275755.2 → NP_001262684.1  uncharacterized protein Dmel_CG43102, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262684.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHP1
    Conserved Domains (2) summary
    pfam00621
    Location:1505 → 1687
    RhoGEF; RhoGEF domain
    cl17171
    Location:1679 → 1818
    PH-like; Pleckstrin homology-like domain

  3. NM_142397.3 → NP_650654.2  uncharacterized protein Dmel_CG43102, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650654.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEF7
    Conserved Domains (2) summary
    pfam00621
    Location:1505 → 1687
    RhoGEF; RhoGEF domain
    cl17171
    Location:1679 → 1818
    PH-like; Pleckstrin homology-like domain

  4. NM_001260227.2 → NP_001247156.1  uncharacterized protein Dmel_CG43102, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247156.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6L3
    Conserved Domains (2) summary
    pfam00621
    Location:1576 → 1758
    RhoGEF; RhoGEF domain
    cl17171
    Location:1750 → 1889
    PH-like; Pleckstrin homology-like domain

  5. NM_001300454.1 → NP_001287383.1  uncharacterized protein Dmel_CG43102, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287383.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LIC0
    Conserved Domains (3) summary
    pfam00621
    Location:932 → 1114
    RhoGEF; RhoGEF domain
    sd00039
    Location:1592 → 1643
    7WD40; WD40 repeat [structural motif]
    cl17171
    Location:1106 → 1245
    PH-like; Pleckstrin homology-like domain

  6. NM_001260228.2 → NP_001247157.1  uncharacterized protein Dmel_CG43102, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247157.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K728
    Conserved Domains (3) summary
    pfam00621
    Location:599 → 781
    RhoGEF; RhoGEF domain
    sd00039
    Location:1259 → 1310
    7WD40; WD40 repeat [structural motif]
    cl17171
    Location:773 → 912
    PH-like; Pleckstrin homology-like domain

  7. NM_142396.3 → NP_650653.1  uncharacterized protein Dmel_CG43102, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650653.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEF9
    Related
    FBpp0293550
    Conserved Domains (1) summary
    pfam00621
    Location:158 → 340
    RhoGEF; RhoGEF domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6L3 A0A0B4K6L3
A0A0B4K728 A0A0B4K728
A0A0B4KHP1 A0A0B4KHP1
A0A0B4LIC0 A0A0B4LIC0
Q9VEF7 Q9VEF7
Q9VEF9 Q9VEF9

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