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Atg8b Autophagy-related 8b [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42132, updated on 9-Dec-2024

Summary

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Official Symbol
Atg8bprovided by FlyBase
Official Full Name
Autophagy-related 8bprovided by FlyBase
Primary source
FLYBASE:FBgn0038539
Locus tag
Dmel_CG12334
See related
AllianceGenome:FB:FBgn0038539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
atg8; Atg8; ATG8; atg8b; atg8B; Atg8B; ATG8b; ATG8B; CG12334; dAtg8; dAtg8b; Dmel\CG12334
Summary
Predicted to enable several functions, including phosphatidylethanolamine binding activity; protein tag activity; and ubiquitin protein ligase binding activity. Involved in macroautophagy. Located in autophagosome. Is expressed in adult heart and organism. Orthologous to human GABARAPL1 (GABA type A receptor associated protein like 1) and GABARAPL3 (GABA type A receptor associated protein like 3 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Atg8b in Genome Data Viewer
Location:
90C2-90C2; 3-61 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17724410..17725063, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13550146..13550766, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene osa Neighboring gene long non-coding RNA:CR46035 Neighboring gene Peroxinectin-like Neighboring gene Leucine-rich repeat-containing G protein-coupled receptor 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Atg8 family proteins, LIR/AIM motifs and other interaction modes. Rogov VV, et al. Autophagy Rep, 2023 Dec 31. PMID 38214012, Free PMC Article
  2. Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster. Mason JS, et al. PLoS One, 2018. PMID 29329306, Free PMC Article
  3. Autophagic paintings: In the frontier of art and science. Valko A. Autophagy, 2019 Nov. PMID 31455131, Free PMC Article
  4. β-Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP-activated protein kinase-dependent increase in autophagy. Yang S, et al. Aging Cell, 2015 Dec. PMID 26120775, Free PMC Article
  5. Mitofusin gain and loss of function drive pathogenesis in Drosophila models of CMT2A neuropathy. El Fissi N, et al. EMBO Rep, 2018 Aug. PMID 29898954, Free PMC Article

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The two autophagy-related proteins 8a and 8b play distinct physiological roles in Drosophila.
    Title: The two autophagy-related proteins 8a and 8b play distinct physiological roles in Drosophila.
  2. Analysis of Drosophila Atg8 proteins reveals multiple lipidation-independent roles.
    Title: Analysis of Drosophila Atg8 proteins reveals multiple lipidation-independent roles.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tag activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macroautophagy IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in autophagosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Autophagy-related 8b
Names
Atg8b-PA
Atg8b-PB
CG12334-PA
CG12334-PB
autophagy related gene 8
autophagy-specific gene 8b

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17724410..17725063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316551.1 → NP_001303480.1  Autophagy-related 8b, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEG5
    Conserved Domains (1) summary
    cd01611
    Location:7 → 118
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein

  2. NM_142392.3 → NP_650649.1  Autophagy-related 8b, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650649.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEG5
    Related
    FBpp0082957
    Conserved Domains (1) summary
    cd01611
    Location:7 → 118
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K1J3 Q7K1J3
Q9VEG5 Q9VEG5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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