sll slalom [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sllprovided by FlyBase
Official Full Name: slalomprovided by FlyBase
Primary source: FLYBASE:FBgn0038524
Locus tag: Dmel_CG7623
See related: AllianceGenome:FB:FBgn0038524
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1422/14; anon-WO0118547.555; anon-WO0172774.85; CG7623; Dmel\CG7623; l(3)S142214; Sll
Summary: Enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate transport; heparan sulfate proteoglycan biosynthetic process; and oocyte dorsal/ventral axis specification. Located in Golgi apparatus. Is expressed in adult head. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 26. Orthologous to human SLC35B2 (solute carrier family 35 member B2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (17606106..17608541)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (13431828..13434263)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Sll encodes an adenosine-3'-phosphate-5'-phosphosulfate transporter essential for development in Drosophila.
Title: Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in 3'-phosphoadenosine 5'-phosphosulfate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed