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sds22 sds22 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42091, updated on 9-Dec-2024

Summary

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Official Symbol
sds22provided by FlyBase
Official Full Name
sds22provided by FlyBase
Primary source
FLYBASE:FBgn0028992
Locus tag
Dmel_CG5851
See related
AllianceGenome:FB:FBgn0028992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5851; CT18355; Dmel\CG5851; Sds22
Summary
Involved in establishment or maintenance of polarity of follicular epithelium; establishment or maintenance of polarity of larval imaginal disc epithelium; and negative regulation of cell population proliferation. Located in apical part of cell and cytoplasm. Is expressed in adult head and organism. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See sds22 in Genome Data Viewer
Location:
90A5-90A5; 3-60 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17391594..17393020)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13217316..13218742)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44256 Neighboring gene Brf RNA polymerase III subunit Neighboring gene long non-coding RNA:CR43196 Neighboring gene lute Neighboring gene antisense RNA:CR44160 Neighboring gene Cellular Repressor of E1A-stimulated Genes Neighboring gene Sur-8 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing. Moura M, et al. Elife, 2017 May 2. PMID 28463114, Free PMC Article
  2. Minimal functional domains of the core polarity regulator Dlg. Khoury MJ, et al. Biol Open, 2022 Jul 15. PMID 35722710, Free PMC Article
  3. Cell-type-specific mechanical response and myosin dynamics during retinal lens development in Drosophila. Blackie L, et al. Mol Biol Cell, 2020 Jun 15. PMID 32320320, Free PMC Article
  4. PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit. Kunda P, et al. Curr Biol, 2012 Feb 7. PMID 22209527
  5. A chromosome separation checkpoint: A midzone Aurora B gradient mediates a chromosome separation checkpoint that regulates the anaphase-telophase transition. Maiato H, et al. Bioessays, 2015 Mar. PMID 25470791

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in establishment or maintenance of polarity of follicular epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of polarity of larval imaginal disc epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sds22
Names
CG5851-PA
sds22-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17391594..17393020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142362.4 → NP_650619.1  sds22 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650619.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3W5, Q9VEK8
    Related
    FBpp0082877
    Conserved Domains (3) summary
    sd00033
    Location:43 → 62
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:83 → 125
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:61 → 117
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U3W5 Q9U3W5
Q9VEK8 Q9VEK8

Gene LinkOut

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