U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arl6IP1 ADP-ribosylation factor-like 6 interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42027, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Arl6IP1provided by FlyBase
Official Full Name
ADP-ribosylation factor-like 6 interacting protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0038453
Locus tag
Dmel_CG10326
See related
AllianceGenome:FB:FBgn0038453
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Al6IP1; ARL6IP1; CG10326; Dmel\CG10326
Summary
Involved in endoplasmic reticulum tubular network membrane organization and mitochondrion organization. Is active in endoplasmic reticulum tubular network. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; central brain primordium; and ganglia. Used to study hereditary spastic paraplegia and hereditary spastic paraplegia 61. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ARL6 interacting reticulophagy regulator 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Arl6IP1 in Genome Data Viewer
Location:
89D6-89D6; 3-59 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16643605..16645171)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12469327..12470893)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Fasciclin 1 Neighboring gene nonA-like Neighboring gene uncharacterized protein Neighboring gene Chaperonin containing TCP1 subunit 3 Neighboring gene Methyltransferase like 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Loss of the Mitochondrial Fission GTPase Drp1 Contributes to Neurodegeneration in a Drosophila Model of Hereditary Spastic Paraplegia. Fowler PC, et al. Brain Sci, 2020 Sep 17. PMID 32957716, Free PMC Article
  2. Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia. Byrne DJ, et al. Acta Neuropathol Commun, 2022 Mar 28. PMID 35346366, Free PMC Article
  3. ER-shaping proteins are required for ER and mitochondrial network organization in motor neurons. Fowler PC, et al. Hum Mol Genet, 2016 Jul 1. PMID 27170313
  4. BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. Fujiyama-Nakamura S, et al. Genes Cells, 2009 Aug. PMID 19624754
  5. A deficiency screen of the 3rd chromosome for dominant modifiers of the Drosophila ER integral membrane protein, Jagunal. Ascencio G, et al. G3 (Bethesda), 2023 Jul 5. PMID 36932646, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum tubular network IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ADP-ribosylation factor-like 6 interacting protein 1
Names
Arl6IP1-PA
Arl6IP1-PB
CG10326-PA
CG10326-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16643605..16645171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142313.3 → NP_650570.1  ADP-ribosylation factor-like 6 interacting protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650570.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VES1
    UniProtKB/TrEMBL
    A0A0B4KG41
    Related
    FBpp0082786
    Conserved Domains (1) summary
    pfam02453
    Location:29 → 187
    Reticulon; Reticulon

  2. NM_001275718.1 → NP_001262647.1  ADP-ribosylation factor-like 6 interacting protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262647.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VES1
    UniProtKB/TrEMBL
    A0A0B4KG41
    Conserved Domains (1) summary
    pfam02453
    Location:29 → 187
    Reticulon; Reticulon
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KG41 A0A0B4KG41
Q9VES1.1 Q9VES1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools