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Gyc89Da Guanylyl cyclase at 89Da [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42001, updated on 9-Dec-2024

Summary

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Official Symbol
Gyc89Daprovided by FlyBase
Official Full Name
Guanylyl cyclase at 89Daprovided by FlyBase
Primary source
FLYBASE:FBgn0038435
Locus tag
Dmel_CG14885
See related
AllianceGenome:FB:FBgn0038435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14885; Dmel\CG14885; Gyc-89Da; GYCb
Summary
Enables enzyme binding activity and guanylate cyclase activity. Involved in nitric oxide-cGMP-mediated signaling; response to hypoxia; and response to reactive oxygen species. Part of guanylate cyclase complex, soluble. Is expressed in anterior wing margin; chemosensory neurons; labellum; and tarsal segment. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Gyc89Da in Genome Data Viewer
Location:
89B17-89B17; 3-58 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16472601..16475477)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12298323..12301199)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 5 Neighboring gene antisense RNA:CR46029 Neighboring gene Guanylyl cyclase at 89Db Neighboring gene Dihydrofolate reductase Neighboring gene Succinate dehydrogenase assembly factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Atypical soluble guanylyl cyclases control brain size in Drosophila. Prieto D, et al. MicroPubl Biol, 2024. PMID 39185012, Free PMC Article
  2. Drosophila gustatory preference behaviors require the atypical soluble guanylyl cyclases. Vermehren-Schmaedick A, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2011 Jul. PMID 21350862
  3. Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors. Morton DB. J Biol Chem, 2004 Dec 3. PMID 15485853
  4. Comparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster. Morton DB, et al. J Insect Sci, 2005. PMID 16341244, Free PMC Article
  5. Preliminary characterization of two atypical soluble guanylyl cyclases in the central and peripheral nervous system of Drosophila melanogaster. Langlais KK, et al. J Exp Biol, 2004 Jun. PMID 15159437

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gyc-89Da only forms an active guanylyl cyclase when co-expressed with Gyc-88E.
    Title: Comparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in nitric oxide-cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxygen levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to reactive oxygen species IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of guanylate cyclase complex, soluble IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of guanylate cyclase complex, soluble IC
Inferred by Curator
more info
 PubMed 
part_of guanylate cyclase complex, soluble IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanylyl cyclase at 89Da
Names
CG14885-PB
CG14885-PC
Gyc89Da-PB
Gyc89Da-PC
NP_001036718.1
NP_001036719.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16472601..16475477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001043254.2 → NP_001036719.1  guanylyl cyclase at 89Da, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036719.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KI63, Q4V501, Q9VEU6
    UniProtKB/TrEMBL
    B7Z0S6
    Conserved Domains (4) summary
    smart00044
    Location:457 → 643
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:485 → 662
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:2 → 161
    HNOB; Haem-NO-binding
    pfam07701
    Location:218 → 476
    HNOBA; Heme NO binding associated

  2. NM_001043253.1 → NP_001036718.1  guanylyl cyclase at 89Da, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036718.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KI63, Q4V501, Q9VEU6
    UniProtKB/TrEMBL
    B7Z0S6
    Conserved Domains (4) summary
    smart00044
    Location:457 → 643
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:485 → 662
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam07700
    Location:2 → 161
    HNOB; Haem-NO-binding
    pfam07701
    Location:218 → 476
    HNOBA; Heme NO binding associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z0S6 B7Z0S6
Q9VEU6.2 Q9VEU6

Gene LinkOut

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