U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ema endosomal maturation defective [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41992, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
emaprovided by FlyBase
Official Full Name
endosomal maturation defectiveprovided by FlyBase
Primary source
FLYBASE:FBgn0038427
Locus tag
Dmel_CG12753
See related
AllianceGenome:FB:FBgn0038427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12753; Dmel\CG12753; Ema
Summary
Enables small GTPase binding activity. Involved in endosomal transport and endosome to lysosome transport. Located in Golgi apparatus and membrane. Colocalizes with late endosome. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Addison's disease; multiple sclerosis; rheumatoid arthritis; and type 1 diabetes mellitus. Orthologous to human CLEC16A (C-type lectin domain containing 16A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ema in Genome Data Viewer
Location:
89B16-89B16; 3-58 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16436880..16441661, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12262602..12267383, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Farnesyl transferase beta subunit Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene Tetratricopeptide repeat domain 1 Neighboring gene uncharacterized protein Neighboring gene Pak3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A role for the membrane Golgi protein Ema in autophagy. Kim S, et al. Autophagy, 2012 Aug. PMID 22713284
  2. Drosophila Golgi membrane protein Ema promotes autophagosomal growth and function. Kim S, et al. Proc Natl Acad Sci U S A, 2012 May 1. PMID 22493244, Free PMC Article
  3. The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases. Bayat V, et al. Curr Opin Neurobiol, 2011 Feb. PMID 20832291, Free PMC Article
  4. The structure and population genetics of the breakpoints associated with the cosmopolitan chromosomal inversion In(3R)Payne in Drosophila melanogaster. Matzkin LM, et al. Genetics, 2005 Jul. PMID 15781702, Free PMC Article
  5. 5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity. Bernstein AI, et al. Hum Mol Genet, 2016 Jun 15. PMID 27060332, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
endosomal maturation defective
Names
CG12753-PA
CG12753-PB
CG12753-PC
ema-PA
ema-PB
ema-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16436880..16441661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275706.1 → NP_001262635.1  endosomal maturation defective, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262635.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH88
    Conserved Domains (1) summary
    pfam09758
    Location:50 → 199
    FPL; uncharacterized conserved protein

  2. NM_001038969.2 → NP_001034058.1  endosomal maturation defective, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034058.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VEV4
    Conserved Domains (1) summary
    pfam09758
    Location:50 → 199
    FPL; uncharacterized conserved protein

  3. NM_142285.2 → NP_650542.1  endosomal maturation defective, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650542.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5BIH5, Q8MRD4, Q9VEV4
    Related
    FBpp0082766
    Conserved Domains (1) summary
    pfam09758
    Location:50 → 199
    FPL; Uncharacterized conserved protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KH88 A0A0B4KH88
Q9VEV4.2 Q9VEV4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools