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CG6126 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41967, updated on 4-Jan-2025

Summary

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Official Symbol
CG6126provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038407
Locus tag
Dmel_CG6126
See related
AllianceGenome:FB:FBgn0038407
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CT19169; Dmel\CG6126
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Is expressed in several structures, including adult fat body; extraembryonic structure; ganglia; glial cell; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to several human genes including SLC22A16 (solute carrier family 22 member 16). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG6126 in Genome Data Viewer
Location:
89B7-89B7; 3-58 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16198000..16203083, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12023722..12028805, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bicoid interacting protein 1 Neighboring gene sarah Neighboring gene uncharacterized protein Neighboring gene mitochondrial single stranded DNA-binding protein Neighboring gene long non-coding RNA:CR45639 Neighboring gene long non-coding RNA:CR45640

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SLC22 Transporters in the Fly Renal System Regulate Response to Oxidative Stress In Vivo. Zhang P, et al. Int J Mol Sci, 2021 Dec 14. PMID 34948211, Free PMC Article
  2. Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress. Engelhart DC, et al. Int J Mol Sci, 2020 Mar 15. PMID 32183456, Free PMC Article
  3. The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila. Han Y, et al. Elife, 2017 Aug 14. PMID 28806173, Free PMC Article
  4. Glial solute carrier transporters in Drosophila and mice. Featherstone DE. Glia, 2011 Sep. PMID 21732427
  5. Barrier mechanisms in the Drosophila blood-brain barrier. Hindle SJ, et al. Front Neurosci, 2014. PMID 25565944, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6126-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16198000..16203083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142271.3 → NP_650528.1  uncharacterized protein Dmel_CG6126 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650528.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961R9, Q9VEX8
    Related
    FBpp0082730
    Conserved Domains (2) summary
    cd06174
    Location:130 → 501
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:15 → 510
    2A0119; cation transport protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q961R9 Q961R9

Gene LinkOut

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