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mor moira [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41942, updated on 4-Jan-2025

Summary

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Official Symbol
morprovided by FlyBase
Official Full Name
moiraprovided by FlyBase
Primary source
FLYBASE:FBgn0002783
Locus tag
Dmel_CG18740
See related
AllianceGenome:FB:FBgn0002783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bap155; BAP155; CG18740; CG4275; Dmel\CG18740; dmMOIRA; E(E2F)3B; l(3)89B1; Moi; Moira; MOIRA; Mor; MOR; MOR/BAP155; Swi3D
Summary
Predicted to enable histone binding activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; negative regulation of neuroblast proliferation; and regulation of DNA-templated transcription. Located in nucleus. Part of brahma complex. Is expressed in several structures, including CNS glial cell; cuboidal/columnar epithelium; embryonic/larval midgut primordium; ganglia; and gut section. Used to study Coffin-Siris syndrome and opportunistic bacterial infectious disease. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 8 and hydrocephalus. Orthologous to human SMARCC1 (SWI/SNF related BAF chromatin remodeling complex subunit C1) and SMARCC2 (SWI/SNF related BAF chromatin remodeling complex subunit C2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mor in Genome Data Viewer
Location:
89A8-89A11; 3-58 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15968134..15972913, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11793856..11798635, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Retinoblastoma-family protein 2 Neighboring gene Helicase 89B Neighboring gene long non-coding RNA:CR44133 Neighboring gene serpent

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intraproteomic networks: new forays into predicting interaction partners. Aravind L, et al. Genome Res, 2002 Aug. PMID 12176922
  2. Transcription co-activator SAYP mediates the action of STAT activator. Panov VV, et al. Nucleic Acids Res, 2012 Mar. PMID 22123744, Free PMC Article
  3. GBAF, a small BAF sub-complex with big implications: a systematic review. Innis SM, et al. Epigenetics Chromatin, 2020 Nov 3. PMID 33143733, Free PMC Article
  4. Characterization of the extended Myb-like DNA-binding domain of trithorax group protein Zeste. Mohrmann L, et al. J Biol Chem, 2002 Dec 6. PMID 12354778
  5. Protein complex-based analysis framework for high-throughput data sets. Vinayagam A, et al. Sci Signal, 2013 Feb 26. PMID 23443684, Free PMC Article

See all (242) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in imaginal disc-derived wing margin morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing vein morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of innate immune response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of brahma complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
moira
Names
Bap155/Moira
CG18740-PA
CG18740-PB
MOIRA
brahma associated protein 155 kDa
brahma-associated protein 155
brahma-like
mor-PA
mor-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15968134..15972913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202301.2 → NP_001189230.1  moira, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189230.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDA0, Q7KPY3
    Conserved Domains (5) summary
    COG5259
    Location:415 → 991
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam04433
    Location:453 → 538
    SWIRM; SWIRM domain
    pfam16495
    Location:898 → 967
    SWIRM-assoc_1; SWIRM-associated region 1
    pfam16496
    Location:6 → 446
    SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
    pfam16498
    Location:738 → 801
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

  2. NM_079649.4 → NP_524373.1  moira, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524373.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76489, O96970, Q7KPY3, Q9VF03
    Related
    FBpp0082692
    Conserved Domains (5) summary
    COG5259
    Location:417 → 742
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam04433
    Location:453 → 538
    SWIRM; SWIRM domain
    pfam16495
    Location:962 → 1031
    SWIRM-assoc_1; SWIRM-associated region 1
    pfam16496
    Location:6 → 446
    SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
    pfam16498
    Location:738 → 801
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JDA0 A0A0B4JDA0
Q7KND4 Q7KND4
Q7KPY3 Q7KPY3
Q8MSY3 Q8MSY3
Q9VF03 Q9VF03

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