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Sap47 Synapse-associated protein 47kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41938, updated on 9-Dec-2024

Summary

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Official Symbol
Sap47provided by FlyBase
Official Full Name
Synapse-associated protein 47kDprovided by FlyBase
Primary source
FLYBASE:FBgn0013334
Locus tag
Dmel_CG8884
See related
AllianceGenome:FB:FBgn0013334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8884; Dmel\CG8884; dsap-47; SAP 47; SAP-47; sap47; SAP47
Summary
Involved in associative learning and regulation of short-term neuronal synaptic plasticity. Located in synapse. Is expressed in adult brain; adult head; embryonic/larval head sense organ; embryonic/larval neuromuscular junction; and ganglia. Orthologous to human SYAP1 (synapse associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Sap47 in Genome Data Viewer
Location:
89A8-89A8; 3-58 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15935100..15962124)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11760822..11787846)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 7 Neighboring gene uncharacterized protein Neighboring gene black pearl Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Behavioral and synaptic plasticity are impaired upon lack of the synaptic protein SAP47. Saumweber T, et al. J Neurosci, 2011 Mar 2. PMID 21368063, Free PMC Article
  2. The sap47 gene of Drosophila melanogaster codes for a novel conserved neuronal protein associated with synaptic terminals. Reichmuth C, et al. Brain Res Mol Brain Res, 1995 Aug. PMID 7494462
  3. Synapsin is required to "boost" memory strength for highly salient events. Kleber J, et al. Learn Mem, 2016 Jan. PMID 26670182, Free PMC Article
  4. Targeted mutagenesis of the Sap47 gene of Drosophila: flies lacking the synapse associated protein of 47 kDa are viable and fertile. Funk N, et al. BMC Neurosci, 2004 Apr 29. PMID 15117418, Free PMC Article
  5. BSD: a novel domain in transcription factors and synapse-associated proteins. Doerks T, et al. Trends Biochem Sci, 2002 Apr. PMID 11943536

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila.
    Title: Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila.
  2. SAP47 is required for proper behavior and synaptic plasticity.
    Title: Behavioral and synaptic plasticity are impaired upon lack of the synaptic protein SAP47.
  3. The conserved synaptic protein SAP47 of Drosophila is not essential for basic synaptic function. The Sap47 gene region may be refractory to targeted mutagenesis by homologous recombination
    Title: Targeted mutagenesis of the Sap47 gene of Drosophila: flies lacking the synapse associated protein of 47 kDa are viable and fertile.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in associative learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of short-term neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of short-term neuronal synaptic plasticity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Synapse-associated protein 47kD
Names
CG8884-PA
CG8884-PB
CG8884-PC
CG8884-PD
CG8884-PE
CG8884-PF
CG8884-PG
CG8884-PI
CG8884-PJ
CG8884-PK
CG8884-PL
CG8884-PM
Sap47-PA
Sap47-PB
Sap47-PC
Sap47-PD
Sap47-PE
Sap47-PF
Sap47-PG
Sap47-PI
Sap47-PJ
Sap47-PK
Sap47-PL
Sap47-PM

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15935100..15962124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370053.1 → NP_001356917.1  Synapse-associated protein 47kD, isoform L [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4D6K1Y5
    Conserved Domains (1) summary
    smart00751
    Location:274 → 324
    BSD; domain in transcription factors and synapse-associated proteins

  2. NM_001300421.1 → NP_001287350.1  Synapse-associated protein 47kD, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287350.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LH71
    Conserved Domains (1) summary
    smart00751
    Location:274 → 324
    BSD; domain in transcription factors and synapse-associated proteins

  3. NM_169688.3 → NP_732092.2  Synapse-associated protein 47kD, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732092.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LH71
    Conserved Domains (1) summary
    smart00751
    Location:274 → 324
    BSD; domain in transcription factors and synapse-associated proteins

  4. NM_169684.3 → NP_732088.1  Synapse-associated protein 47kD, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732088.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2Z5, Q24502, Q24503, Q8INC9, Q960T2, Q9VF07
    Related
    FBpp0082658
    Conserved Domains (1) summary
    smart00751
    Location:297 → 347
    BSD; domain in transcription factors and synapse-associated proteins

  5. NM_169690.3 → NP_732094.1  Synapse-associated protein 47kD, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732094.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960T2
    Related
    FBpp0082659
    Conserved Domains (1) summary
    smart00751
    Location:297 → 347
    BSD; domain in transcription factors and synapse-associated proteins

  6. NM_079647.4 → NP_524371.1  Synapse-associated protein 47kD, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524371.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960T2
    Related
    FBpp0082663
    Conserved Domains (1) summary
    smart00751
    Location:274 → 324
    BSD; domain in transcription factors and synapse-associated proteins

  7. NM_169686.3 → NP_732090.1  Synapse-associated protein 47kD, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732090.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2Z5, Q24502, Q24503, Q8INC9, Q960T2, Q9VF07
    Related
    FBpp0082661
    Conserved Domains (1) summary
    smart00751
    Location:297 → 347
    BSD; domain in transcription factors and synapse-associated proteins

  8. NM_169687.3 → NP_732091.1  Synapse-associated protein 47kD, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732091.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2Z5, Q24502, Q24503, Q8INC9, Q960T2, Q9VF07
    Related
    FBpp0082662
    Conserved Domains (1) summary
    smart00751
    Location:297 → 347
    BSD; domain in transcription factors and synapse-associated proteins

  9. NM_001370054.1 → NP_001356918.1  Synapse-associated protein 47kD, isoform M [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4D6K595
    Conserved Domains (1) summary
    smart00751
    Location:281 → 331
    BSD; domain in transcription factors and synapse-associated proteins

  10. NM_169689.3 → NP_732093.1  Synapse-associated protein 47kD, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732093.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960T2
    Related
    FBpp0082664
    Conserved Domains (1) summary
    smart00751
    Location:281 → 331
    BSD; domain in transcription factors and synapse-associated proteins

  11. NM_169685.3 → NP_732089.1  Synapse-associated protein 47kD, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732089.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2Z5, Q24502, Q24503, Q8INC9, Q960T2, Q9VF07
    Related
    FBpp0082660
    Conserved Domains (1) summary
    smart00751
    Location:297 → 347
    BSD; domain in transcription factors and synapse-associated proteins

  12. NM_001275688.1 → NP_001262617.1  Synapse-associated protein 47kD, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262617.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YDF6
    Conserved Domains (1) summary
    smart00751
    Location:271 → 321
    BSD; domain in transcription factors and synapse-associated proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LH71 A0A0B4LH71
A0A4D6K1Y5 A0A4D6K1Y5
A0A4D6K595 A0A4D6K595
F3YDF6 F3YDF6
Q960T2.1 Q960T2

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