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AOX4 Aldehyde oxidase 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41897, updated on 9-Dec-2024

Summary

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Official Symbol
AOX4provided by FlyBase
Official Full Name
Aldehyde oxidase 4provided by FlyBase
Primary source
FLYBASE:FBgn0038350
Locus tag
Dmel_CG18516
See related
AllianceGenome:FB:FBgn0038350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18516; DmAO4; Dmel\CG18516
Summary
Predicted to enable aldehyde oxidase activity. Predicted to be involved in cellular aldehyde metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See AOX4 in Genome Data Viewer
Location:
88F7-88F8; 3-57 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15548628..15552833, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11374350..11378555, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Aldehyde oxidase 2 Neighboring gene Aldehyde oxidase 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The four aldehyde oxidases of Drosophila melanogaster have different gene expression patterns and enzyme substrate specificities. Marelja Z, et al. J Exp Biol, 2014 Jun 15. PMID 24737760, Free PMC Article
  2. Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1. Terao M, et al. J Biol Chem, 2001 Dec 7. PMID 11562361
  3. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. Colca JR, et al. PLoS One, 2013. PMID 23690925, Free PMC Article
  4. Drosophila Relish Activating lncRNA-CR33942 Transcription Facilitates Antimicrobial Peptide Expression in Imd Innate Immune Response. Zhou H, et al. Front Immunol, 2022. PMID 35720331, Free PMC Article
  5. Identification of genes expressed during Drosophila melanogaster gastrulation by using subtractive hybridization. González-Agüero M, et al. Gene, 2005 Jan 31. PMID 15716118

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aldehyde metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
aldehyde oxidase 4
Names
AOX4-PA
CG18516-PA
NP_650478.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15548628..15552833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142221.2 → NP_650478.1  aldehyde oxidase 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650478.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VF50
    Related
    FBpp0082604
    Conserved Domains (6) summary
    smart01008
    Location:542 → 648
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    PLN02906
    Location:24 → 1240
    PLN02906; xanthine dehydrogenase
    pfam00941
    Location:203 → 378
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01799
    Location:80 → 153
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:690 → 1174
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:388 → 489
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VF50 Q9VF50

Gene LinkOut

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