U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AOX1 Aldehyde oxidase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41894, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
AOX1provided by FlyBase
Official Full Name
Aldehyde oxidase 1provided by FlyBase
Primary source
FLYBASE:FBgn0267408
Locus tag
Dmel_CG18522
See related
AllianceGenome:FB:FBgn0267408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18522; CT42272; DmAO1; Dmel\CG18522; lpo; LPO; Po; PO
Summary
Enables pyridoxal oxidase activity. Involved in pyridoxal metabolic process. Predicted to be located in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic ventral epidermis; embryonic/larval midgut; and epithelium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See AOX1 in Genome Data Viewer
Location:
88F7-88F7; 3-57 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15532137..15537292, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11357859..11363014, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Aldehyde oxidase 2 Neighboring gene Aldehyde oxidase 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A third locus (ipo) affecting pyridoxal oxidase in Drosophila melanogaster. Collins JF, et al. Genetics, 1969 Apr. PMID 5364965, Free PMC Article
  2. Gene regulation in Drosophila: independent expression of closely linked, related structural loci. Dickinson WJ, et al. Biochem Genet, 1976 Oct. PMID 827284
  3. Tissue-specific and substrate-specific detection of aldehyde and pyridoxal oxidase in larval and imaginal tissues of Drosophila melanogaster. Cypher JJ, et al. Biochem Genet, 1982 Apr. PMID 6808989
  4. Molybdenum hydroxylases in Drosophila. II. Molybdenum cofactor in xanthine dehydrogenase, aldehyde oxidase and pyridoxal oxidase. Warner CK, et al. Mol Gen Genet, 1981. PMID 6950197
  5. Multiple molecular forms of xanthine dehydrogenase and related enzymes. Glassman E, et al. Ann N Y Acad Sci, 1968 Jun 14. PMID 5251871

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde oxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal oxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in pyridoxal metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
aldehyde oxidase 1
Names
AOX1-PA
CG18522-PA
low-pyridoxal-oxidase
pyridoxal oxidase
NP_650475.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15532137..15537292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142218.2 → NP_650475.1  aldehyde oxidase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650475.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VF53
    Related
    FBpp0082608
    Conserved Domains (7) summary
    smart01008
    Location:555 → 666
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    PLN02906
    Location:28 → 1259
    PLN02906; xanthine dehydrogenase
    cd00207
    Location:4 → 85
    fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...
    pfam01799
    Location:86 → 159
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:711 → 1192
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:399 → 502
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain
    cl19922
    Location:211 → 373
    FAD_binding_4; FAD binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VF53 Q9VF53

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools