Rbp RIM-binding protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rbpprovided by FlyBase
Official Full Name: RIM-binding proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0262483
Locus tag: Dmel_CG43073
See related: AllianceGenome:FB:FBgn0262483
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14867; CG31302; CG43073; CG5143; CG5152; Dmel\CG43073; drbp; DRBP; dRIM-BP; rbp; RBP; rim-bp; RIM-BP; RimBP
Old locus tag: Dmel_CG14867; Dmel_CG31302
Summary: Involved in cytoskeletal matrix organization at active zone; neuromuscular synaptic transmission; and presynaptic active zone organization. Located in cytoskeleton of presynaptic active zone. Is active in neuromuscular junction and presynaptic active zone cytoplasmic component. Is expressed in adult head and embryonic/larval neuromuscular junction. Human ortholog(s) of this gene implicated in dystonia 22, adult-onset and dystonia 22, juvenile-onset. Orthologous to several human genes including RIMBP2 (RIMS binding protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 88F3-88F4; 3-57 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15374635..15402543)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11200424..11228265)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RIM-binding protein couples synaptic vesicle recruitment to release sites.
Title: RIM-binding protein couples synaptic vesicle recruitment to release sites.
The authors show in atomic detail that RBP C-terminal Src-homology 3 domains bind a proline-rich (PxxP) motif of Aplip1/JIP1 with submicromolar affinity.
Title: A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones.
Drosophila Rab3-interacting molecule (RIM)-binding protein (DRBP) is essential not only for the integrity of the active zone scaffold but also for exocytotic neurotransmitter release
Title: RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.
RIM functions to regulate Ca(2+) channel accumulation but is not a Rab3 effector for release machinery distribution across release sites
Title: RIM promotes calcium channel accumulation at active zones of the Drosophila neuromuscular junction.
homeostatic plasticity appears to require two genetically separable processes, the enhancement of presynaptic calcium influx and a RIM-dependent modulation of the readily-releasable pool
Title: RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in cytoskeletal matrix organization at active zone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic active zone organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoskeleton of presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone cytoplasmic component	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RIM-binding protein

Names: CG43073-PF; CG43073-PG; CG43073-PI; CG43073-PJ; CG43073-PK; CG43073-PL; CG43073-PM; CG43073-PN; CG43073-PO; Rab3-interacting molecule (RIM)-binding protein; Rbp-PF; Rbp-PG; Rbp-PI; Rbp-PJ; Rbp-PK; Rbp-PL; Rbp-PM; Rbp-PN; Rbp-PO

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

15374635..15402543

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202298.3 → NP_001189227.1 RIM-binding protein, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189227.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JDC9

Conserved Domains (4) summary

cd12012
Location:1319 → 1380

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1446 → 1507

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd00063
Location:844 → 907

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl17036
Location:609 → 677

SH3; Src Homology 3 domain superfamily
NM_169652.5 → NP_732028.4 RIM-binding protein, isoform K [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q9VF66

Conserved Domains (4) summary

cd12012
Location:1223 → 1284

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1350 → 1411

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd00063
Location:775 → 838

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl17036
Location:551 → 608

SH3; Src Homology 3 domain superfamily
NM_001316579.1 → NP_001303508.1 RIM-binding protein, isoform M [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUV2

Conserved Domains (4) summary

cd12012
Location:1240 → 1301

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1367 → 1428

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd00063
Location:765 → 828

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl17036
Location:541 → 598

SH3; Src Homology 3 domain superfamily
NM_001275672.2 → NP_001262601.1 RIM-binding protein, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262601.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KG12

Conserved Domains (4) summary

cd12012
Location:1274 → 1335

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1401 → 1462

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd00063
Location:799 → 862

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl17036
Location:566 → 634

SH3; Src Homology 3 domain superfamily
NM_169654.4 → NP_732030.4 RIM-binding protein, isoform L [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q86BP0

Conserved Domains (4) summary

cd12012
Location:1238 → 1299

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1365 → 1426

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd00063
Location:763 → 826

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl17036
Location:541 → 598

SH3; Src Homology 3 domain superfamily
NM_001275673.2 → NP_001262602.1 RIM-binding protein, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262602.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGQ6

Conserved Domains (4) summary

cd12012
Location:1238 → 1299

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1365 → 1426

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd00063
Location:790 → 853

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl17036
Location:566 → 623

SH3; Src Homology 3 domain superfamily
NM_001202297.3 → NP_001189226.1 RIM-binding protein, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189226.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JCX2

Conserved Domains (4) summary

cd12012
Location:1292 → 1353

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1419 → 1480

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd00063
Location:844 → 907

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl17036
Location:609 → 677

SH3; Src Homology 3 domain superfamily
NM_001170149.3 → NP_001163620.3 RIM-binding protein, isoform N [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JIL7

Conserved Domains (4) summary

cd12012
Location:1266 → 1327

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1393 → 1454

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd00063
Location:791 → 854

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl17036
Location:556 → 624

SH3; Src Homology 3 domain superfamily
NM_169653.4 → NP_732029.4 RIM-binding protein, isoform O [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q86BS0

Conserved Domains (4) summary

cd12012
Location:1224 → 1285

SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd12013
Location:1351 → 1412

SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins

cd00063
Location:776 → 839

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl17036
Location:541 → 609

SH3; Src Homology 3 domain superfamily

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4JCX2		A0A0B4JCX2
A0A0B4JDC9		A0A0B4JDC9
A0A0B4KG12		A0A0B4KG12
A0A0B4KGQ6		A0A0B4KGQ6
A0A126GUV2		A0A126GUV2
E1JIL7		E1JIL7
Q86BP0		Q86BP0
Q86BS0		Q86BS0
Q9VF66		Q9VF66