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Fkbp39 FK506-binding protein 39kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41860, updated on 9-Dec-2024

Summary

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Official Symbol
Fkbp39provided by FlyBase
Official Full Name
FK506-binding protein 39kDprovided by FlyBase
Primary source
FLYBASE:FBgn0013269
Locus tag
Dmel_CG6226
See related
AllianceGenome:FB:FBgn0013269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6226; Dmel\CG6226; FK506-bp1; FK506bp1; fkbp39; FKbp39; FKBP39; IFK506-bp1
Summary
Enables FK506 binding activity and juvenile hormone response element binding activity. Involved in juvenile hormone mediated signaling pathway and negative regulation of macroautophagy. Located in heterochromatin. Is expressed in several structures, including embryonic/larval midgut primordium; gonad; head epidermis primordium; mesoderm; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Fkbp39 in Genome Data Viewer
Location:
88F1-88F1; 3-57 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15331584..15333133, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11157306..11158855, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene easter Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene Cytoplasmic FMR1 interacting protein Neighboring gene N-acetylglucosamine kinase Neighboring gene Seryl-tRNA synthetase, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FKBP39, a Drosophila member of a family of proteins that bind the immunosuppressive drug FK506. Theopold U, et al. Gene, 1995 Apr 24. PMID 7538962
  2. Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetramer with partly disordered tentacle-like C-terminal segments. Kozłowska M, et al. Sci Rep, 2017 Jan 11. PMID 28074868, Free PMC Article
  3. Molecular determinants of Drosophila immunophilin FKBP39 nuclear localization. Orłowski M, et al. Biol Chem, 2018 Apr 25. PMID 29337690
  4. FKBP39 Controls the Larval Stage JH Activity and Development in Drosophila melanogaster. Wang X, et al. Insects, 2022 Mar 28. PMID 35447772, Free PMC Article
  5. Nuclear immunophilin FKBP39 from Drosophila melanogaster drives spontaneous liquid-liquid phase separation. Tarczewska A, et al. Int J Biol Macromol, 2020 Nov 15. PMID 32615218

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
    Title: FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
  2. Nuclear immunophilin FKBP39 from Drosophila melanogaster drives spontaneous liquid-liquid phase separation.
    Title: Nuclear immunophilin FKBP39 from Drosophila melanogaster drives spontaneous liquid-liquid phase separation.
  3. The results show that FKBP39 possesses a specific nuclear localization signal (NLS) in close proximity to a putative helix-turn-helix (HTH) motif and FKBP39 may bind DNA in vivo and in vitro.
    Title: Molecular determinants of Drosophila immunophilin FKBP39 nuclear localization.
  4. Analyses of full-length FKBP39 and its isolated NPL domain suggested that the distal regions of the polypeptide chain influence and determine the quaternary conformation of the nucleoplasmin-like protein.
    Title: Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetramer with partly disordered tentacle-like C-terminal segments.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables FK506 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables juvenile hormone response element binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in juvenile hormone mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FK506-binding protein 39kD
Names
CG6226-PA
FK506 binding protein-1
FK506-binding protein 1
FK506-binding protein of 39 kDa
Fkbp39-PA
NP_524364.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15331584..15333133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079640.3 → NP_524364.2  FK506-binding protein 39kD [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524364.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54397, Q9VF88
    Related
    FBpp0082574
    Conserved Domains (1) summary
    pfam00254
    Location:262 → 354
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54397.2 P54397

Gene LinkOut

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