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l(3)neo43 lethal (3) neo43 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41851, updated on 4-Jan-2025

Summary

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Official Symbol
l(3)neo43provided by FlyBase
Official Full Name
lethal (3) neo43provided by FlyBase
Primary source
FLYBASE:FBgn0011476
Locus tag
Dmel_CG14865
See related
AllianceGenome:FB:FBgn0011476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14865; Dmel\CG14865
Summary
Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 22. Orthologous to human COX16 (cytochrome c oxidase assembly factor COX16). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See l(3)neo43 in Genome Data Viewer
Location:
88E11-88E11; 3-56 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15277981..15278668, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11103703..11104390, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Zinc/iron regulated transporter-related protein 88E Neighboring gene Centrosomal protein 190kD Neighboring gene antisense RNA:CR46081 Neighboring gene uncharacterized protein Neighboring gene MORF-related gene 15 Neighboring gene Tropomyosin 1 Neighboring gene uncharacterized protein Neighboring gene Tropomyosin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division. Butcher RD, et al. J Cell Sci, 2004 Mar 1. PMID 14996941
  2. Genetic and molecular analysis of region 88E9;88F2 in Drosophila melanogaster, including the ear gene related to human factors involved in lineage-specific leukemias. Zraly CB, et al. Genetics, 2002 Mar. PMID 11901121, Free PMC Article
  3. Insertional mutagenesis of the Drosophila genome with single P elements. Cooley L, et al. Science, 1988 Mar 4. PMID 2830671
  4. Ultra-deep sequencing of ribosome-associated poly-adenylated RNA in early Drosophila embryos reveals hundreds of conserved translated sORFs. Li H, et al. DNA Res, 2016 Dec. PMID 27559081, Free PMC Article
  5. Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila. Ding K, et al. G3 (Bethesda), 2022 Dec 1. PMID 36200850, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lethal (3) neo43
Names
CG14865-PD
CG14865-PE
l(3)neo43-PD
l(3)neo43-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15277981..15278668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275660.2 → NP_001262589.2  lethal (3) neo43, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1B2AKH8, A8E6N3, Q29QH7, Q9VF98
    Conserved Domains (1) summary
    pfam14138
    Location:16 → 94
    COX16; Cytochrome c oxidase assembly protein COX16

  2. NM_142186.3 → NP_650443.3  lethal (3) neo43, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1B2AKH8, A8E6N3, Q29QH7, Q9VF98
    Conserved Domains (1) summary
    pfam14138
    Location:16 → 94
    COX16; Cytochrome c oxidase assembly protein COX16
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VF98 Q9VF98

Gene LinkOut

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